HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
医学研究院・医学院  >
雑誌発表論文等  >

The Serotonergic Projection from the Median Raphe Nucleus to the Ventral Hippocampus is Involved in the Retrieval of Fear Memory Through the Corticotropin-Releasing Factor Type 2 Receptor

フルテキスト
Supplemental_figures.pdfSupplemental Figures372.03 kBPDF見る/開く
Neu35-6_1271-1278.pdf480.02 kBPDF見る/開く
この文献へのリンクには次のURLを使用してください:http://hdl.handle.net/2115/44115

タイトル: The Serotonergic Projection from the Median Raphe Nucleus to the Ventral Hippocampus is Involved in the Retrieval of Fear Memory Through the Corticotropin-Releasing Factor Type 2 Receptor
著者: Ohmura, Yu 著作を一覧する
Izumi, Takeshi 著作を一覧する
Yamaguchi, Taku 著作を一覧する
Tsutsui-Kimura, Iku 著作を一覧する
Yoshida, Takayuki 著作を一覧する
Yoshioka, Mitsuhiro 著作を一覧する
キーワード: corticotropin-releasing hormone
hippocampus
fear
memory
5-HT
median raphe nucleus
発行日: 2010年 5月
出版者: Nature Publishing Group
誌名: Neuropsychopharmacology
巻: 35
号: 6
開始ページ: 1271
終了ページ: 1278
出版社 DOI: 10.1038/npp.2009.229
抄録: Several different studies have separately established that serotonin, corticotropin-releasing factor (CRF) receptors, and the hippocampus are involved in fear memory retrieval. The main aim of the present study is to connect these separate studies. To assess the levels of anxiety/fear, we employed the contextual fear-conditioning test and the elevated plus maze test as memory-dependent and -independent tasks, respectively. We injected CRF receptor antagonists or vehicle into the median raphe nucleus (MRN) 10 minutes before behavioral tests. As a result, 1000 ng of astressin 2B (CRF2 receptor antagonist), but not 250 ng of antalarmin (CRF1 receptor antagonist), significantly suppressed the expression rate of freezing behavior in the contextual fear-conditioning test. However, in the elevated plus maze test, there was no difference between astressin 2B-injected rats and saline-injected rats in the time spent in open arms. Neither the amount of exploratory behavior nor the moving distance in the EPM of astressin 2B-injected rats differed from that of vehicle-injected rats. Moreover, when we assessed the extracellular serotonin release in the ventral hippocampus in freely moving rats through in vivo microdialysis, it was shown that the blockade of the CRF2 receptor in the MRN suppressed serotonin release in the ventral hippocampus during fear memory retrieval. These results indicated that endogenous CRF and/or related ligands released in the MRN could activate the CRF2 receptor and stimulate serotonin release in the ventral hippocampus, thereby inducing fear memory retrieval.
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/44115
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 吉岡 充弘

 

本サイトに関するご意見・お問い合わせは repo at lib.hokudai.ac.jp へお願いします。 - 北海道大学