| Title: | Clinical significance of minimal residual disease in adult acute lymphoblastic leukemia |
| Authors: | Kikuchi, Misato Browse this author |
| Tanaka, Junji Browse this author →KAKEN DB |
| Kondo, Takeshi Browse this author |
| Hashino, Satoshi Browse this author |
| Kasai, Masaharu Browse this author |
| Kurosawa, Mitsutoshi Browse this author |
| Iwasaki, Hiroshi Browse this author |
| Morioka, Masanobu Browse this author |
| Kawamura, Tsugumichi Browse this author |
| Masauzi, Nobuo Browse this author |
| Fukuhara, Takashi Browse this author |
| Kakinoki, Yasutaka Browse this author |
| Kobayashi, Hajime Browse this author |
| Noto, Satoshi Browse this author |
| Asaka, Masahiro Browse this author |
| Imamura, Masahiro Browse this author |
| Keywords: | MRD |
| Adult ALL |
| Allogeneic transplantation |
| Polymerase chain reaction |
| Flow cytometry |
| Issue Date: | Oct-2010 |
| Publisher: | Springer Japan |
| Journal Title: | International Journal of Hematology |
| Volume: | 92 |
| Issue: | 3 |
| Start Page: | 481 |
| End Page: | 489 |
| Publisher DOI: | 10.1007/s12185-010-0670-1 |
| PMID: | 20830615 |
| Abstract: | Monitoring minimal residual disease (MRD) in patients with acute lymphoblastic leukemia (ALL) is a useful way for assessing treatment response and relapse. We studied the value of MRD and showed a correlation with relapse for 34 adult patients with ALL. MRD was evaluated by real-time quantitative polymerase chain reaction (RQ-PCR) with probes derived from fusion chimeric genes (BCR/ABL) (n = 12) or PCR-based detection of clonal immunoglobulin and T-cell receptor gene rearrangements (n = 16), or both (n = 6). We analyzed 27 of the 34 patients who could be examined for MRD on day 100 after induction therapy. The overall survival (OS) rate (45.0%) and relapse-free survival (RFS) rate (40.0%) at 2 years in CR patients with MRD level ≥ 10^[-3] (n = 12) were significantly lower than those in CR patients with MRD level < 10^[-3] (n = 15) (OS rate: 79.0%, RFS rate: 79.4%) (log-rank test, P = 0.017 and 0.0007). We also applied multicolor flow cytometry for comparison with MRD results analyzed by PCR methods. The comparison of results obtained in 27 follow-up samples showed consistency in 17 samples (63.0%) (P = 0.057). MRD analysis on day 100 is important for treatment decision in adult ALL. |
| Rights: | The final publication is available at www.springerlink.com |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/44159 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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