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Relationship between Barkhof criteria and the clinical features of multiple sclerosis in northern Japan

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Title: Relationship between Barkhof criteria and the clinical features of multiple sclerosis in northern Japan
Authors: Nakamura, M. Browse this author
Houzen, H. Browse this author
Niino, M. Browse this author
Tanaka, K. Browse this author
Sasaki, H. Browse this author
Keywords: multiple sclerosis
magnetic resonance imaging
spinal cord
Issue Date: Dec-2009
Publisher: SAGE Publications
Journal Title: Multiple Sclerosis
Volume: 15
Issue: 12
Start Page: 1450
End Page: 1458
Publisher DOI: 10.1177/1352458509350305
Abstract: Background and Objective: We previously reported that the prevalence of MS in Tokachi Province of Hokkaido has increased from 8.6 to 13.1 per 100,000 individuals between 2001 and 2006. Here, we studied the frequency of MS patients who fulfill the Barkhof criteria and identified their common features. Subjects: All 47 subjects in our previous study, who fulfilled Poser's criteria, were included in this study. Results: Of these, 33 satisfied the Barkhof criteria. In 2006, 9.2 per 100,000 MS patients fulfilled the Barkhof criteria; the percentage of patients who fulfilled these criteria was significantly higher among patients born after 1960 than among those born before 1960 (84.3% and 40.0%, respectively). The proportion of patients with conventional MS (C-MS) who fulfilled the Barkhof criteria was higher than that of patients with opticospinal MS (OS-MS) who fulfilled these criteria (93.9% and 71.4%, respectively). Longitudinally extensive spinal cord lesions (LESCLs) were not associated with the brain lesions defined in the Barkhof criteria (Barkhof brain lesions). Conclusion: In Tokachi Province, the increased percentage of MS patients who fulfill the Barkhof criteria was associated with increased C-MS incidence and increase in the proportion of C-MS patients with Barkhof brain lesions among people born after 1960.
Rights: The final, definitive version of this article has been published in the Journal, Multiple Sclerosis, 15(12), 2009 of publication, © The Author(s) 2009 by SAGE Publications Ltd at the Multiple Sclerosis page: on SAGE Journals Online:
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 新野 正明

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