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Molecular phylogeny of a newfound hantavirus in the Japanese shrew mole (Urotrichus talpoides).
| Title: | Molecular phylogeny of a newfound hantavirus in the Japanese shrew mole (Urotrichus talpoides). |
| Authors: | Arai, Satoru Browse this author | | Ohdachi, Satoshi D. Browse this author →KAKEN DB | | Asakawa, Mitsuhiko Browse this author | | Kang, Hae Ji Browse this author | | Mocz, Gabor Browse this author | | Arikawa, Jiro Browse this author →KAKEN DB | | Okabe, Nobuhiko Browse this author | | Yanagihara, Richard Browse this author |
| Keywords: | Hantavirus | | Mole | | Shrew | | Phylogeny | | Host Switching |
| Issue Date: | 21-Oct-2008 |
| Publisher: | National Academy of Sciences |
| Journal Title: | Proceedings of the National Academy of Sciences of the United States of America |
| Volume: | 105 |
| Issue: | 42 |
| Start Page: | 16296 |
| End Page: | 16301 |
| Publisher DOI: | 10.1073/pnas.0808942105 |
| PMID: | 18854415 |
| Abstract: | Recent molecular evidence of genetically distinct hantaviruses in shrews, captured in widely separated geographical regions, corroborates decades-old reports of hantavirus antigens in shrew tissues. Apart from challenging the conventional view that rodents are the principal reservoir hosts, the recently identified soricid-borne hantaviruses raise the possibility that other soricomorphs, notably talpids, similarly harbor hantaviruses. In analyzing RNA extracts from lung tissues of the Japanese shrew mole (Urotrichus talpoides), captured in Japan between February and April 2008, a hantavirus genome, designated Asama virus (ASAV), was detected by RT-PCR. Pairwise alignment and comparison of the S-, M-, and L-segment nucleotide and amino acid sequences indicated that ASAV was genetically more similar to hantaviruses harbored by shrews than by rodents. However, the predicted secondary structure of the ASAV nucleocapsid protein was similar to that of rodent- and shrew-borne hantaviruses, exhibiting the same coiled-coil helix at the amino terminus. Phylogenetic analyses, using the maximum-likelihood method and other algorithms, consistently placed ASAV with recently identified soricine shrew-borne hantaviruses, suggesting a possible host-switching event in the distant past. The discovery of a mole-borne hantavirus enlarges our concepts about the complex evolutionary history of hantaviruses. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/44321 |
| Appears in Collections: | 低温科学研究所 (Institute of Low Temperature Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 大舘 智志
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