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Molecular phylogeny of a newfound hantavirus in the Japanese shrew mole (Urotrichus talpoides).

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/44321

Title: Molecular phylogeny of a newfound hantavirus in the Japanese shrew mole (Urotrichus talpoides).
Authors: Arai, Satoru Browse this author
Ohdachi, Satoshi D. Browse this author →KAKEN DB
Asakawa, Mitsuhiko Browse this author
Kang, Hae Ji Browse this author
Mocz, Gabor Browse this author
Arikawa, Jiro Browse this author →KAKEN DB
Okabe, Nobuhiko Browse this author
Yanagihara, Richard Browse this author
Keywords: Hantavirus
Mole
Shrew
Phylogeny
Host Switching
Issue Date: 21-Oct-2008
Publisher: National Academy of Sciences
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Volume: 105
Issue: 42
Start Page: 16296
End Page: 16301
Publisher DOI: 10.1073/pnas.0808942105
PMID: 18854415
Abstract: Recent molecular evidence of genetically distinct hantaviruses in shrews, captured in widely separated geographical regions, corroborates decades-old reports of hantavirus antigens in shrew tissues. Apart from challenging the conventional view that rodents are the principal reservoir hosts, the recently identified soricid-borne hantaviruses raise the possibility that other soricomorphs, notably talpids, similarly harbor hantaviruses. In analyzing RNA extracts from lung tissues of the Japanese shrew mole (Urotrichus talpoides), captured in Japan between February and April 2008, a hantavirus genome, designated Asama virus (ASAV), was detected by RT-PCR. Pairwise alignment and comparison of the S-, M-, and L-segment nucleotide and amino acid sequences indicated that ASAV was genetically more similar to hantaviruses harbored by shrews than by rodents. However, the predicted secondary structure of the ASAV nucleocapsid protein was similar to that of rodent- and shrew-borne hantaviruses, exhibiting the same coiled-coil helix at the amino terminus. Phylogenetic analyses, using the maximum-likelihood method and other algorithms, consistently placed ASAV with recently identified soricine shrew-borne hantaviruses, suggesting a possible host-switching event in the distant past. The discovery of a mole-borne hantavirus enlarges our concepts about the complex evolutionary history of hantaviruses.
Type: article (author version)
URI: http://hdl.handle.net/2115/44321
Appears in Collections:低温科学研究所 (Institute of Low Temperature Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 大舘 智志

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