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Genetic variants in mannose receptor gene (MRC1) confer susceptibility to increased risk of sarcoidosis
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Title: | Genetic variants in mannose receptor gene (MRC1) confer susceptibility to increased risk of sarcoidosis |
Authors: | Hattori, Takeshi Browse this author | Konno, Satoshi Browse this author | Takahashi, Ayumu Browse this author | Isada, Akira Browse this author | Shimizu, Kaoruko Browse this author | Shimizu, Kenichi Browse this author | Taniguchi, Natsuko Browse this author | Gao, Peisong Browse this author | Yamaguchi, Etsuro Browse this author | Hizawa, Nobuyuki Browse this author | Huang, Shau-Ku Browse this author | Nishimura, Masaharu Browse this author |
Issue Date: | 28-Oct-2010 |
Publisher: | BioMed Central |
Journal Title: | BMC Medical Genetics |
Volume: | 11 |
Start Page: | 151 |
Publisher DOI: | 10.1186/1471-2350-11-151 |
Abstract: | Background: Mannose receptor (MR) is a member of the C-type lectin receptor family involved in pathogen molecular-pattern recognition and thought to be critical in shaping host immune response. The aim of this study was to investigate potential associations of genetic variants in the MRC1 gene with sarcoidosis. Methods: Nine single nucleotide polymorphisms (SNPs), encompassing the MRC1 gene, were genotyped in a total of 605 Japanese consisting of 181 sarcoidosis patients and 424 healthy controls. Results: Suggestive evidence of association between rs691005 SNP and risk of sarcoidosis was observed independent of sex and age in a recessive model (P = 0.001). Conclusions: These results suggest that MRC1 is an important candidate gene for sarcoidosis. This is the first study to imply that genetic variants in MRC1, a major member of the C-type lectin, contribute to the development of sarcoidosis. |
Rights: | http://creativecommons.org/licenses/by/2.0 |
Type: | article |
URI: | http://hdl.handle.net/2115/44388 |
Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 今野 哲
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