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Genetic variants in mannose receptor gene (MRC1) confer susceptibility to increased risk of sarcoidosis

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Title: Genetic variants in mannose receptor gene (MRC1) confer susceptibility to increased risk of sarcoidosis
Authors: Hattori, Takeshi Browse this author
Konno, Satoshi Browse this author
Takahashi, Ayumu Browse this author
Isada, Akira Browse this author
Shimizu, Kaoruko Browse this author
Shimizu, Kenichi Browse this author
Taniguchi, Natsuko Browse this author
Gao, Peisong Browse this author
Yamaguchi, Etsuro Browse this author
Hizawa, Nobuyuki Browse this author
Huang, Shau-Ku Browse this author
Nishimura, Masaharu Browse this author
Issue Date: 28-Oct-2010
Publisher: BioMed Central
Journal Title: BMC Medical Genetics
Volume: 11
Start Page: 151
Publisher DOI: 10.1186/1471-2350-11-151
Abstract: Background: Mannose receptor (MR) is a member of the C-type lectin receptor family involved in pathogen molecular-pattern recognition and thought to be critical in shaping host immune response. The aim of this study was to investigate potential associations of genetic variants in the MRC1 gene with sarcoidosis. Methods: Nine single nucleotide polymorphisms (SNPs), encompassing the MRC1 gene, were genotyped in a total of 605 Japanese consisting of 181 sarcoidosis patients and 424 healthy controls. Results: Suggestive evidence of association between rs691005 SNP and risk of sarcoidosis was observed independent of sex and age in a recessive model (P = 0.001). Conclusions: These results suggest that MRC1 is an important candidate gene for sarcoidosis. This is the first study to imply that genetic variants in MRC1, a major member of the C-type lectin, contribute to the development of sarcoidosis.
Type: article
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 今野 哲

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