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Comparative evaluation of growth inhibitory effect of stereoisomers of fucoxanthin in human cancer cell lines

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Title: Comparative evaluation of growth inhibitory effect of stereoisomers of fucoxanthin in human cancer cell lines
Authors: Nakazawa, Y. Browse this author
Sashima, T. Browse this author
Hosokawa, M. Browse this author →KAKEN DB
Miyashita, K. Browse this author →KAKEN DB
Keywords: Fucoxanthin
Isomer specificity
Human cancer cells
Apoptosis
Issue Date: Jan-2009
Publisher: Elsevier
Journal Title: Journal of Functional Foods
Volume: 1
Issue: 1
Start Page: 88
End Page: 97
Publisher DOI: 10.1016/j.jff.2008.09.015
Abstract: Inhibitory effects of geometrical isomers of fucoxanthin - characteristic carotenoid of brown seaweeds - on the growth of various cancer cells and on human leukemia (HL-60), colon cancer (Caco-2) and prostate cancer cells (PC-3 and LNCap) were comparatively evaluated. All trans fucoxanthin was the major geometrical isomer (∼88%) found in the fresh brown seaweed (Undaria pinnatifida) apart from a small amount of 13-cis and 13'-cis isomers (∼9%). Incubation of the fucoxanthin isomeric mixtures, all trans fucoxanthin with a small amount of 13-cis and 13'-cis isomers, produced 9'-cis isomer (5%) and increased the contents of 13-cis, and 13'-cis isomers (27%). The antiproliferative effect of the mixture of 13-cis and 13'-cis isomers was stronger than all other geometrical isomers evaluated in the study. The inhibition of growth of HL-60 cells was higher in case of 13'-cis isomer followed by 13-cis and all-trans isomers. The potent inhibitory effect of 13-cis and 13'-cis fucoxanthin on HL-60 cells and Caco-2 cells could possibly be due to their higher apoptosis inducing activity.
Type: article (author version)
URI: http://hdl.handle.net/2115/44502
Appears in Collections:水産科学院・水産科学研究院 (Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 宮下 和夫

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