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Hokkaido University Collection of Scholarly and Academic Papers >
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Comparative evaluation of growth inhibitory effect of stereoisomers of fucoxanthin in human cancer cell lines
| Title: | Comparative evaluation of growth inhibitory effect of stereoisomers of fucoxanthin in human cancer cell lines |
| Authors: | Nakazawa, Y. Browse this author | | Sashima, T. Browse this author | | Hosokawa, M. Browse this author →KAKEN DB | | Miyashita, K. Browse this author →KAKEN DB |
| Keywords: | Fucoxanthin | | Isomer specificity | | Human cancer cells | | Apoptosis |
| Issue Date: | Jan-2009 |
| Publisher: | Elsevier |
| Journal Title: | Journal of Functional Foods |
| Volume: | 1 |
| Issue: | 1 |
| Start Page: | 88 |
| End Page: | 97 |
| Publisher DOI: | 10.1016/j.jff.2008.09.015 |
| Abstract: | Inhibitory effects of geometrical isomers of fucoxanthin - characteristic carotenoid of brown seaweeds - on the growth of various cancer cells and on human leukemia (HL-60), colon cancer (Caco-2) and prostate cancer cells (PC-3 and LNCap) were comparatively evaluated. All trans fucoxanthin was the major geometrical isomer (∼88%) found in the fresh brown seaweed (Undaria pinnatifida) apart from a small amount of 13-cis and 13'-cis isomers (∼9%). Incubation of the fucoxanthin isomeric mixtures, all trans fucoxanthin with a small amount of 13-cis and 13'-cis isomers, produced 9'-cis isomer (5%) and increased the contents of 13-cis, and 13'-cis isomers (27%). The antiproliferative effect of the mixture of 13-cis and 13'-cis isomers was stronger than all other geometrical isomers evaluated in the study. The inhibition of growth of HL-60 cells was higher in case of 13'-cis isomer followed by 13-cis and all-trans isomers. The potent inhibitory effect of 13-cis and 13'-cis fucoxanthin on HL-60 cells and Caco-2 cells could possibly be due to their higher apoptosis inducing activity. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/44502 |
| Appears in Collections: | 水産科学院・水産科学研究院 (Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 宮下 和夫
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