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Airflow limitation and airway dimensions assessed per bronchial generation in older asthmatics

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Title: Airflow limitation and airway dimensions assessed per bronchial generation in older asthmatics
Authors: Shimizu, Kaoruko Browse this author
Hasegawa, Masaru Browse this author
Makita, Hironi Browse this author
Nasuhara, Yasuyuki Browse this author
Konno, Satoshi Browse this author
Nishimura, Masaharu Browse this author →KAKEN DB
Keywords: Airway remodeling
Pulmonary function
Issue Date: Dec-2010
Publisher: Elsevier
Journal Title: Respiratory Medicine
Volume: 104
Issue: 12
Start Page: 1809
End Page: 1816
Publisher DOI: 10.1016/j.rmed.2010.06.013
PMID: 20615680
Abstract: Background: Computed tomography (CT) has been used for non-invasive quantitative assessment of airway dimensions, potentially showing airway remodeling, in asthma. However, most studies have examined either only one airway or only airways in anatomically unidentified cross-sections. Using software capable of precisely identifying the generation of airways and measuring airway dimensions perpendicular to the long axis of airways, we examined, in older patients with stable asthma, how inter-subject variation in airway dimensions correlated among the 3rd to 6th generation of airways, and then examined relationships between airway dimensions of each generation and indices of airflow limitation. Methods: Subjects aged ≥ 55 years old comprised 59 asthmatic patients who underwent CT and pulmonary function tests on the same day. We measured airway wall area (WA%) and inner luminal area (Ai) from the 3rd to the 6th generation of eight bronchi in the right lung. Results: Excellent correlations were identified for both WA% and Ai among the generations (r = 0.744-0.930 for WA%) when we took the average of all measured bronchi per generation as a personal representative value. Significant correlations of airflow limitation indices with both WA% and Ai/BSA were found at each of the 3rd to 6th generations with similar correlation coefficients (WA% for FEV1%predicted, r = -0.410 to -0.556). Conclusions: In older patients with stable asthma, airway wall thickening and narrowing might occur in a parallel manner through 3rd to 6th generation airways. Airway dimensions at these areas of airways may thus have significant and similar correlations with indices of airflow limitation.
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 西村 正治

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