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C-type lectins do not act as functional receptors for filovirus entry into cells

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Title: C-type lectins do not act as functional receptors for filovirus entry into cells
Authors: Matsuno, Keita Browse this author
Nakayama, Eri Browse this author
Noyori, Osamu Browse this author
Marzi, Andrea Browse this author
Ebihara, Hideki Browse this author
Irimura, Tatsuro Browse this author →KAKEN DB
Feldmann, Heinz Browse this author
Takada, Ayato Browse this author →KAKEN DB
Keywords: Filovirus
Virus entry
C-type lectin
Issue Date: 3-Dec-2010
Publisher: Elsevier
Journal Title: Biochemical and Biophysical Research Communications
Volume: 403
Issue: 1
Start Page: 144
End Page: 148
Publisher DOI: 10.1016/j.bbrc.2010.10.136
Abstract: Cellular C-type lectins have been reported to facilitate filovirus infection by binding to glycans on filovirus glycoprotein (GP). However, it is not clearly known whether interaction between C-type lectins and GP mediates all the steps of virus entry (i.e., attachment, internalization, and membrane fusion). In this study, we generated vesicular stomatitis viruses pseudotyped with mutant GPs that have impaired structures of the putative receptor binding regions and thus reduced ability to infect the monkey kidney cells that are routinely used for virus propagation. We found that infectivities of viruses with the mutant GPs dropped in C-type lectin-expressing cells, parallel with those in the monkey kidney cells, whereas binding activities of these GPs to the C-type lectins were not correlated with the infectivities. These results suggest that C-type lectin-mediated entry of filoviruses requires other cellular molecule(s) that may be involved in virion internalization or membrane fusion.
Type: article (author version)
URI: http://hdl.handle.net/2115/44634
Appears in Collections:人獣共通感染症リサーチセンター (Research Center for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 高田 礼人

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