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The ubiquitin ligase Riplet is essential for RIG-I-dependent innate immune responses to RNA virus infection.

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/44745

Title: The ubiquitin ligase Riplet is essential for RIG-I-dependent innate immune responses to RNA virus infection.
Other Titles: The essential role of a ubiquitin ligase, Riplet, in RIG-I-dependent antiviral innate immune responses
Authors: Oshiumi, Hiroyuki Browse this author
Miyashita, Moeko Browse this author
Inoue, Naokazu Browse this author
Okabe, Masaru Browse this author
Matsumoto, Misako Browse this author
Seya, Tsukasa Browse this author
Issue Date: 16-Dec-2010
Publisher: Cell press
Journal Title: Cell Host & Microbe
Volume: 8
Issue: 6
Start Page: 496
End Page: 509
Publisher DOI: 10.1016/j.chom.2010.11.008
PMID: 21147464
Abstract: RNA virus infection is recognized by the RIG-I-like receptors RIG-I and MDA5, which induce antiviral responses including the production of type I inter- ferons (IFNs) and proinflammatory cytokines. RIG-I is regulated by Lys63-linked polyubiquitination, and three E3 ubiquitin ligases, RNF125, TRIM25, and Riplet, are reported to target RIG-I for ubiquitination. To examine the importance of Riplet in vivo, we generated Riplet-deficient mice. Fibroblasts, macro- phages, and conventional dendritic cells from Riplet- deficient animals were defective for the production of IFN and other cytokines in response to infection with several RNA viruses. However, Riplet was dispens- able for the production of IFN in response to B-DNA and DNA virus infection. Riplet deficiency abolished RIG-I activation during RNA virus infection, and the mutant mice were more susceptible to vesicular stomatitis virus infection than wild-type mice. These data indicate that Riplet is essential for regulating RIG-I-mediated innate immune response against RNA virus infection in vivo.
Type: article (author version)
URI: http://hdl.handle.net/2115/44745
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 瀬谷 司

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