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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >
The ubiquitin ligase Riplet is essential for RIG-I-dependent innate immune responses to RNA virus infection.
| Title: | The ubiquitin ligase Riplet is essential for RIG-I-dependent innate immune responses to RNA virus infection. |
| Other Titles: | The essential role of a ubiquitin ligase, Riplet, in RIG-I-dependent antiviral innate immune responses |
| Authors: | Oshiumi, Hiroyuki Browse this author | | Miyashita, Moeko Browse this author | | Inoue, Naokazu Browse this author | | Okabe, Masaru Browse this author | | Matsumoto, Misako Browse this author | | Seya, Tsukasa Browse this author |
| Issue Date: | 16-Dec-2010 |
| Publisher: | Cell press |
| Journal Title: | Cell Host & Microbe |
| Volume: | 8 |
| Issue: | 6 |
| Start Page: | 496 |
| End Page: | 509 |
| Publisher DOI: | 10.1016/j.chom.2010.11.008 |
| PMID: | 21147464 |
| Abstract: | RNA virus infection is recognized by the RIG-I-like receptors RIG-I and MDA5, which induce antiviral responses including the production of type I inter- ferons (IFNs) and proinflammatory cytokines. RIG-I is regulated by Lys63-linked polyubiquitination, and three E3 ubiquitin ligases, RNF125, TRIM25, and Riplet, are reported to target RIG-I for ubiquitination. To examine the importance of Riplet in vivo, we generated Riplet-deficient mice. Fibroblasts, macro- phages, and conventional dendritic cells from Riplet- deficient animals were defective for the production of IFN and other cytokines in response to infection with several RNA viruses. However, Riplet was dispens- able for the production of IFN in response to B-DNA and DNA virus infection. Riplet deficiency abolished RIG-I activation during RNA virus infection, and the mutant mice were more susceptible to vesicular stomatitis virus infection than wild-type mice. These data indicate that Riplet is essential for regulating RIG-I-mediated innate immune response against RNA virus infection in vivo. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/44745 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 瀬谷 司
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