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Retinol binding protein 4 in dairy cows : its presence in colostrum and alteration in plasma during fasting, inflammation, and the peripartum period

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Title: Retinol binding protein 4 in dairy cows : its presence in colostrum and alteration in plasma during fasting, inflammation, and the peripartum period
Authors: Eldaim, Mabrouk A. Abd Browse this author
Kamikawa, Akihiro Browse this author
Soliman, Mohamed M. Browse this author
Ahmed, Mohamed M. Browse this author
Okamatsu-Ogura, Yuko Browse this author →KAKEN DB
Terao, Akira Browse this author →KAKEN DB
Miyamoto, Toru Browse this author
Kimura, Kazuhiro Browse this author →KAKEN DB
Keywords: Colostrum
vitamin A
Issue Date: Feb-2010
Publisher: Cambridge University Press
Journal Title: Journal of Dairy Research
Volume: 77
Issue: 1
Start Page: 27
End Page: 32
Publisher DOI: 10.1017/S0022029909990276
PMID: 19785912
Abstract: Retinol-binding protein 4 (RBP4) is a plasma protein involved in retinol transportation, and recent evidence in rodents suggests that RBP4 is also a metabolic regulator that modifies insulin sensitivity. To assess how RBP4 levels are regulated in ruminants, we determined the RBP4 concentrations in bovine plasma and milk using Western blot analysis. Plasma RBP4 levels in non-pregnant non-lactating (control) cows were around 45 μg/ml, which were sustained during 60-h fasting, but decreased significantly 4 h after lipopolysaccharide (LPS) administration. Basal plasma retinol concentration was around 30 μg/dl, but this decreased to approximately one-third and one-half of these values during fasting and 8 h after LPS challenge, respectively. Plasma RBP4 and retinol levels in cows 3-6 d before parturition were comparable to those of the controls. However, on the day of parturition both were significantly decreased and had returned to basal levels by two weeks after calving. Interestingly, RBP4 was clearly detected in colostrum (16.4 ± 5.6 μg/ml) but was only faintly detected in milk from cows at 7 d and 15 d after calving. Retinol concentrations in colostrum were almost 10-fold higher than those in plasma, while those in milk were comparable to those in plasma. These results suggest that RBP4 and retinol levels are independently regulated under physiological and pathophysiological conditions and that RBP4, like retinol, is transferred from maternal stores to calves through colostrum.
Rights: Copyright © Proprietors of Journal of Dairy Research 2009
Type: article
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 木村 和弘

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