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Aberrant expressions of HOX genes in colorectal and hepatocellular carcinomas

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Title: Aberrant expressions of HOX genes in colorectal and hepatocellular carcinomas
Authors: Kanai, Motoshi Browse this author
Hamada, Jun-Ichi Browse this author
Takada, Minoru Browse this author
Asano, Toshimichi Browse this author
Murakawa, Katsuhiko Browse this author
Takahashi, Yoko Browse this author
Murai, Taichi Browse this author
Tada, Mitsuhiro Browse this author
Miyamoto, Masaki Browse this author
Kondo, Satoshi Browse this author
Moriuchi, Tetsuya Browse this author
Issue Date: Mar-2010
Publisher: Spandidos Publications
Journal Title: Oncology Reports
Volume: 23
Issue: 3
Start Page: 843
End Page: 851
Publisher DOI: 10.3892/or_00000706
Abstract: HOX genes are known as master regulator genes which give cells positional information in embryogenesis. In this Study, we compared the expression patterns of 39 HOX genes among human colorectal carcinomas from the right large intestine (cecum, ascending and transverse colon), those from the left large intestine (discending and sigmoid colon, and rectum) and hepatocellular carcinoma. The expression levels of each HOX gene were quantified by analysis based on the real-time RT-PCR. The expression patterns of HOX genes in colorectal and hepatocellular carcinoma tissues differed from those in their normal or non-cancerous tissues. Between the tumor tissues in the right-side large intestine and those in the left-side. different HOX genes were expressed in association with cancer. Further, the expression levels of HOXD8 in liver-metastatic tissues of colorectal carcinomas were as low as in non-cancerous liver tissues, and were significantly lower than those in the primary tissues. These results suggest that dysregulated expressions of HOX genes play an important role in carcinogenesis and malignant progression of colorectal and hepatocellular carcinomas.
Type: article
Appears in Collections:遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 浜田 淳一

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