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RNF43 interacts with NEDL1 and regulates p53-mediated transcription
| Title: | RNF43 interacts with NEDL1 and regulates p53-mediated transcription |
| Authors: | Shinada, Keisuke Browse this author | | Tsukiyama, Tadasuke Browse this author | | Sho, Takuya Browse this author | | Okumura, Fumihiko Browse this author | | Asaka, Masahiro Browse this author | | Hatakeyama, Shigetsugu Browse this author |
| Keywords: | RNF43 | | p53 | | NEDL1 | | ubiquitin | | Colorectal cancer |
| Issue Date: | 7-Jan-2011 |
| Publisher: | Elsevier |
| Journal Title: | Biochemical and Biophysical Research Communications |
| Volume: | 404 |
| Issue: | 1 |
| Start Page: | 143 |
| End Page: | 147 |
| Publisher DOI: | 10.1016/j.bbrc.2010.11.082 |
| PMID: | 21108931 |
| Abstract: | The ubiquitin-proteasomal system plays a crucial role in oncogenesis in colorectal tissues. Recent studies have shown that stability of β-catenin, which functions as an oncogene for colorectal cancer, is regulated by ubiquitin-mediated degradation. It has been reported that a putative E3 ubiquitin ligase, RNF43, is highly expressed in human colorectal carcinoma and that RNF43 promotes cell growth. However, the involvement of RNF43 in carcinogenesis has not been fully elucidated. In this study, we found by using yeast two-hybrid screening that RNF43 binds to NEDD-4-like ubiquitin-protein ligase-1 (NEDL1), which enhances pro-apoptotic activity by p53. In addition, we found that RNF43 also interacts with p53 and that RNF43 suppresses transcriptional activity of p53 in H1299 cells and attenuates apoptosis induced by ultraviolet irradiation. These findings suggest that RNF43 is associated with p53-mediated apoptosis in collaboration with NEDL1 in colorectal carcinogenesis. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/44929 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 畠山 鎮次
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