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The Ras-PI3K Signaling Pathway Is Involved in Clathrin-Independent Endocytosis and the Internalization of Influenza Viruses

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タイトル: The Ras-PI3K Signaling Pathway Is Involved in Clathrin-Independent Endocytosis and the Internalization of Influenza Viruses
著者: Fujioka, Yoichiro 著作を一覧する
Tsuda, Masumi 著作を一覧する
Hattori, Tomoe 著作を一覧する
Sasaki, Junko 著作を一覧する
Sasaki, Takehiko 著作を一覧する
Miyazaki, Tadaaki 著作を一覧する
Ohba, Yusuke 著作を一覧する
発行日: 2011年 1月20日
出版者: Public Library of Science
誌名: PLoS One
巻: 6
号: 1
開始ページ: e16324
出版社 DOI: 10.1371/journal.pone.0016324
抄録: Background: Influenza virus infection causes highly contagious, severe respiratory disorders and gives rise to thousands of deaths every year; however, the efficacy of currently approved defense strategies, including vaccines and neuraminidase inhibitors, is limited because the virus frequently acquires resistance via antigen drift and reassortment. It is therefore important to establish a novel, effective therapeutic strategy that is effective irrespective of viral subtype. Methodology/Principal Findings: Here, we identify the Ras-phosphoinositide 3-kinase (PI3K) signaling pathway as a host-cell regulatory mechanism for influenza virus entry. The binding of Ras to PI3K is specifically involved in clathrinin-dependent endocytosis, endosomal maturation, and intracellular transport of viruses, which result in decreased infectious efficacy of different subtypes of influenza viruses in cells lacking the Ras-PI3K interaction. Moreover, influenza virus infection indeed triggered Ras activation and subsequent PI3K activation in early endosomes. Conclusions/Significance: Taken together, these results demonstrate that the Ras-PI3K signaling axis acts as a host-oriented mechanism for viral internalization. Given that virus incorporation is a process conserved among virus subtypes and species, this signaling pathway may provide a target for potent, well-tolerated prophylactics and therapeutics against a broad range of viruses.
資料タイプ: article
URI: http://hdl.handle.net/2115/44993
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 大場 雄介

 

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