Simple Deuterium Introduction at α-Position of Carbonyl in Diazirinyl Derivatives for Photoaffinity Labeling


Hokkaido University \| Library \| HUSCAP	Advanced Search		言語

	Home
	About HUSCAP
	Open Access Policy

	Browse by Author

Browse
	Communities & Collections

	Scholarly Journals
	Theses
	Doctoral Dissertations Listed by Graduate Schools
	Conference Procs.
	Events

	HUSCAP Senior (in Japanese)

	Societies

	Downloads (country)

For university staff
	How to post your papers to HUSCAP
	Publication of theses
	Helpline about theses publication

Open Archives Compliant

You can search our collection also at:
	Google
	Google Scholar
	CiNii
	IRDB
	OAIster
	NDLTD

Files in This Item:

Het82-1_909-915.pdf

192.06 kB

PDF

Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/45017

Title:	Simple Deuterium Introduction at α-Position of Carbonyl in Diazirinyl Derivatives for Photoaffinity Labeling
Authors:	Murai, Yuta Browse this author
	Takahashi, Miho Browse this author
	Muto, Yasuyuki Browse this author
	Hatanaka, Yasumaru Browse this author
	Hashimoto, Makoto Browse this author
Keywords:	Photoaffinity Labeling
	Diazirine
	Deuterium
	H/D Exchange
	Mass Spectrometry
Issue Date:	31-Dec-2010
Publisher:	Japan Institute of Heterocyclic Chemistry
Journal Title:	Heterocycles
Volume:	82
Issue:	1
Start Page:	909
End Page:	915
Publisher DOI:	10.3987/COM-10-S(E)57
Abstract:	Post-functional deuterium incorporation into diazirinyl acetophenone derivatives is reported. Treatment of the compounds with sodium hydroxide in CH3OD at rt for 10 min achieved deuterium incorporation at α-position of the carbonyl group without decomposition of diazirinyl ring. Further deuterium can introduce by reduction of benzyl carbonyl with triethylsilane-d-TFA. Straightforward deuterium introduction into diazirinyl derivatives may contribute to the functional analysis of low molecular compounds with diazirine-based photoaffinity labeling.
Type:	article (author version)
URI:	http://hdl.handle.net/2115/45017
Appears in Collections:	農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 橋本誠

OAI-PMH ( junii2 , jpcoar_1.0 )

- Hokkaido University