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A feasibility study of a molecular-based patient setup verification method using a parallel-plane PET system

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Title: A feasibility study of a molecular-based patient setup verification method using a parallel-plane PET system
Authors: Yamaguchi, Satoshi Browse this author
Ishikawa, Masayori Browse this author
Bengua, Gerard Browse this author
Sutherland, Kenneth Browse this author
Nishio, Teiji Browse this author
Tanabe, Satoshi Browse this author
Miyamoto, Naoki Browse this author
Suzuki, Ryusuke Browse this author
Shirato, Hiroki Browse this author
Issue Date: 21-Feb-2011
Publisher: IOP Publishing
Journal Title: Physics in Medicine and Biology
Volume: 56
Issue: 4
Start Page: 965
End Page: 977
Publisher DOI: 10.1088/0031-9155/56/4/006
PMID: 21248387
Abstract: A feasibility study of a novel PET-based molecular image guided radiation therapy (m-IGRT) system was conducted by comparing PET-based registration with radiographic registration. We selected a pair of opposing parallel-plane PET systems for the practical implementation. Five different sizes of 18F cylindrical sources (diameter: 8, 12, 16, 24, 32 mm) were used to determine setup errors. PET data acquisition times were 1, 3 and 5 min. Image registration was performed by 5 observers. Setup errors from the PET system were compared with setup errors from image intensifier-based fluoroscopy. The in-plane and cross-plane FWHM of the profile of a 2 mm diameter sources for the parallel-plane PET system were approximately 1.8 mm and 8.1 mm, respectively. The majority of the mean registration errors obtained from the PET-based registration were not significantly different from those obtained from the radiographic registration. Acquisition time did not appear to result in significant differences in the mean registration error. The mean registration error for the PET-based registration was found to be 0.93±0.33 mm. This is not statistically different from the radiographic registration which had mean registration error of 0.92±0.27 mm. Our results suggest that m-IGRT is feasible for clinical use with a parallel plane PET-based registration.
Rights: This is an author-created, un-copyedited version of an article accepted for publication in Physics in Medicine and Biology. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The definitive publisher authenticated version is available online at 10.1088/0031-9155/56/4/006.
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 石川 正純

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