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Emergence of new types of Theileria orientalis in Australian cattle and possible cause of theileriosis outbreaks

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Title: Emergence of new types of Theileria orientalis in Australian cattle and possible cause of theileriosis outbreaks
Authors: Kamau, Joseph Browse this author
de Vos, Albertus J. Browse this author
Playford, Matthew Browse this author
Salim, Bashir Browse this author
Kinyanjui, Peter Browse this author
Sugimoto, Chihiro Browse this author
Issue Date: 21-Feb-2011
Publisher: BioMed Central
Journal Title: Parasites & Vectors
Volume: 4
Start Page: 22
Publisher DOI: 10.1186/1756-3305-4-22
Abstract: Theileria parasites cause a benign infection of cattle in parts of Australia where they are endemic, but have, in recent years, been suspected of being responsible for a number of outbreaks of disease in cattle near the coast of New South Wales. The objective of this study was to identify and characterize the species of Theileria in cattle on six farms in New South Wales where disease outbreaks have occurred, and compare with Theileria from three disease-free farms in Queensland that is endemic for Theileria. Special reference was made to sub-typing of T. orientalis by type-specific PCR and sequencing of the small subunit (SSU) rRNA gene, and sequence analysis of the gene encoding a polymorphic merozoite/piroplasm surface protein (MPSP) that may be under immune selection. Nucleotide sequencing of SSU rRNA and MPSP genes revealed the presence of four Theileria genotypes: T. orientalis (buffeli), T. orientalis (ikeda), T. orientalis (chitose) and T. orientalis type 4 (MPSP) or type C (SSU rRNA). The majority of animals showed mixed infections while a few showed single infection. When MPSP nucleotide sequences were translated into amino acids, base transition did not change amino acid composition of the protein product, suggesting possible silent polymorphism. The occurrence of ikeda and type 4 (type C) previously not reported to occur and silent mutation is thought to have enhanced parasite evasion of the host immune response causing the outbreak.
Rights: http://creativecommons.org/licenses/by/2.0
Type: article
URI: http://hdl.handle.net/2115/45040
Appears in Collections:人獣共通感染症リサーチセンター (Research Center for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 杉本 千尋

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