|
Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >
Levels of Transferrin in Bronchoalveolar Lavage Fluid in Sarcoidosis
| Title: | Levels of Transferrin in Bronchoalveolar Lavage Fluid in Sarcoidosis |
| Authors: | Shigemura, Masahiko Browse this author | | Nasuhara, Yasuyuki Browse this author | | Konno, Satoshi Browse this author | | Hattori, Takeshi Browse this author | | Shimizu, Chikara Browse this author | | Matsuno, Kazuhiko Browse this author | | Nishimura, Masaharu Browse this author |
| Keywords: | Transferrin | | Bronchoalveolar lavage fluid | | Sarcoidosis |
| Issue Date: | Apr-2010 |
| Publisher: | Springer New York |
| Journal Title: | Lung |
| Volume: | 188 |
| Issue: | 2 |
| Start Page: | 151 |
| End Page: | 157 |
| Publisher DOI: | 10.1007/s00408-009-9218-7 |
| PMID: | 20066543 |
| Abstract: | There has been only one report showing high levels of transferrin (Tf) in bronchoalveolar lavage fluid (BALF) in patients with sarcoidosis. The aim of this study is to assess the levels of Tf in both BALF and serum and to examine the relationship between the levels of Tf and other disease markers in sarcoidosis. Subjects were 64 sarcoidosis and 10 healthy controls. Tf in BALF and serum was measured by nephelometric assay. Median Tf levels in BALF from sarcoidosis was 0.70 mg/dl (range, 0.00-3.97), which was significantly higher when compared with controls (0.36 mg/dl; range, 0.00-1.02) (p = 0.005). In contrast, median Tf levels in serum from sarcoidosis was 258 mg/dl (range, 171-383), which was significantly lower when compared with controls (322 mg/dl; range, 234-356) (p = 0.003). Tf levels in BALF were significantly correlated with both the percentage of lymphocytes (r = 0.617, p = 0.001) and serum angiotensin-converting enzyme activity (r = 0.363, p = 0.003) and serum soluble interleukin-2 receptor (r = 0.450, p = 0.001) in sarcoidosis. Levels of Tf in BALF from patients with sarcoidosis were not influenced by smoking status. The levels of Tf in sarcoidosis are high in BALF, but low in serum. Increased levels of Tf in BALF may reflect the disease activity. |
| Rights: | The original publication is available at www.springerlink.com |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/45089 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
Submitter: 南須原 康行
|
