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Analysis of factors decreasing testis weight in MRL mice

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Title: Analysis of factors decreasing testis weight in MRL mice
Authors: Otsuka, Saori Browse this author →KAKEN DB
Namiki, Yuka Browse this author →KAKEN DB
Ichii, Osamu Browse this author →KAKEN DB
Hashimoto, Yoshiharu Browse this author →KAKEN DB
Sasaki, Nobuya Browse this author →KAKEN DB
Endoh, Daiji Browse this author
Kon, Yasuhiro Browse this author →KAKEN DB
Issue Date: Apr-2010
Publisher: Springer New York
Journal Title: Mammalian Genome
Volume: 21
Issue: 3-4
Start Page: 153
End Page: 161
Publisher DOI: 10.1007/s00335-010-9251-0
PMID: 20157820
Abstract: MRL/MpJ (MRL) mouse testes have several unique characteristics, including the appearance of oocytes, the occurrence of metaphase-specific apoptosis of meiotic spermatocytes, and the presence of heat-shock-resistant spermatocytes. In the present study, we used chromosomal mapping to determine the genomic background associated with small testis size in MRL mice. We prepared and analyzed C57BL/6-based congenic mice carrying MRL mouse loci. Quantitative trait loci (QTL) analysis revealed susceptibility loci for small testis size at 100 cM on chromosome (Chr) 1 and at around 80 cM on Chr 2. Analysis with B6.MRLc1 and B6.MRLc2 congenic mice, and double congenic mice, confirmed the QTL data and showed that low testis weight in MRL mice was caused by germ cell apoptosis. Through histological examinations, we found that B6.MRLc1 and B6.MRLc2 mice showed stage-specific apoptosis in their testes, the former at metaphase stage XII and the later at pachytene stage IV. Metaphase-specific apoptosis of spermatocytes occurs due to mutation of the exonuclease 1 (Exo1) gene located at 100 cM on Chr 1. Thus the mutation of the Exo1 gene is also responsible for low testis weight caused by metaphase-specific apoptosis. In conclusion, testis weight is reduced in MRL mice due to apoptosis of germ cells caused by mutations in loci on Chrs 1 and 2.
Rights: The original publication is available at
Type: article (author version)
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 大塚 沙織

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