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Quantitative trait locus analysis of ovarian cysts derived from rete ovarii in MRL/MpJ mice

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Title: Quantitative trait locus analysis of ovarian cysts derived from rete ovarii in MRL/MpJ mice
Authors: Lee, Shin-hyo Browse this author
Ichii, Osamu Browse this author →KAKEN DB
Otsuka, Saori Browse this author →KAKEN DB
Hashimoto, Yoshiharu Browse this author →KAKEN DB
Kon, Yasuhiro Browse this author →KAKEN DB
Issue Date: Apr-2010
Publisher: Springer New York
Journal Title: Mammalian Genome
Volume: 21
Issue: 3-4
Start Page: 162
End Page: 171
Publisher DOI: 10.1007/s00335-010-9254-x
PMID: 20182879
Abstract: MRL/MpJ (MRL) is a model mouse for autoimmune diseases that shows dermatitis, vasculitis, arthritis, and glomerulonephritis. In addition to these immune-associated disorders, we found that aged MRL mice develop ovarian cysts originating from the rete ovarii, which is lined by ciliated or nonciliated epithelium and considered remnants of mesonephric tubules. Ovarian cysts, which are reported to have several sources, are associated with female infertility, but information regarding the genetic etiology of ovarian cysts originating from the rete ovarii is rare. In this study, to elucidate the genetic background of development of ovarian cysts, we performed quantitative trait-locus (QTL) analysis using 120 microsatellite markers, which cover the whole genome of murine chromosomes, and 213 backcross progenies between female MRL and male C57BL/6N mice. The quantitative trait measured was the circumferences of rete ovarii or ovarian cysts. As a result, suggestive linkages were detected on Chr 3, 4, 6, and 11, but significant linkages were located on Chr 14 by interval mapping. We thereby designated the 27.5-cM region of Chr 14 "MRL Rete Ovarian Cysts (mroc)." The peak regions of Chr 4 and 14 in particular showed a close additive interaction (p < 0.00001). From these results, we concluded that multiple loci on Chr 3, 4, 6, 11, and 14 interact to result in development of ovarian cysts in MRL mice.
Rights: The original publication is available at
Type: article (author version)
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 大塚 沙織

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