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An HDAC inhibitor increases AcMNPV gene expression in mammalian cells

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Title: An HDAC inhibitor increases AcMNPV gene expression in mammalian cells
Authors: Fujita, Ryosuke Browse this author
Ohtsuka, Daisuke Browse this author
Sahara, Ken Browse this author
Asano, Shinichiro Browse this author
Bando, Hisanori Browse this author
Keywords: Baculovirus
Histone deacetylation
Gene therapy
Issue Date: Apr-2010
Publisher: Springer Wien
Journal Title: Archives of Virology
Volume: 155
Issue: 4
Start Page: 577
End Page: 581
Publisher DOI: 10.1007/s00705-010-0614-3
PMID: 20186445
Abstract: The baculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV) is used as a safer viral vector in mammalian cells with potential applications in gene therapy. However, the mechanism for the insusceptibility of mammalian cells to proliferative infection by entomopathogenic viruses is not well understood. Here, we studied the significance of epigenetic modifications such as histone acetylation, histone methylation and HP1 accumulation to AcMNPV gene expression in mammalian BHK cells. Real-time PCR and chromatin immunoprecipitation with sodium butyrate revealed an important relationship between viral gene expression and histone acetylation, having implications for a mechanism of suppression of AcMNPV gene expression in BHK cells.
Rights: The original publication is available at
Type: article (author version)
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 伴戸 久徳

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