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Effects of sea squirt (Halocynthia roretzi) lipids on white adipose tissue weight and blood glucose in diabetic/obese KK-Ay mice

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Title: Effects of sea squirt (Halocynthia roretzi) lipids on white adipose tissue weight and blood glucose in diabetic/obese KK-Ay mice
Authors: Mikami, Nana Browse this author
Hosokawa, Masashi Browse this author →KAKEN DB
Miyashita, Kazuo Browse this author →KAKEN DB
Keywords: Halocynthia roretzi
type 2 diabetes
hyperglycemia
blood glucose level
serum adipocytokine secretion
Issue Date: May-2010
Publisher: Spandidos Publications
Journal Title: Molecular Medicine Reports
Volume: 3
Issue: 3
Start Page: 449
End Page: 453
Publisher DOI: 10.3892/mmr_00000278
PMID: 21472260
Abstract: Lipids extracted from Halocynthia roretzi contain n-3 polyunsaturated fatty acids such as eicosapentaenoic acid and docosahexaenoic acid, as well as carotenoids. The aim of the present study was to evaluate the effect of H. roretzi lipids on white adipose tissue (WAT) weight and high blood glucose levels in diabetic/obese KK-Ay mice. H. roretzi lipids were fed to the diabetic/obese KK-Ay mice for 5 weeks. In the mice treated with the H. roretzi lipids compared to control mice, WAT weight was reduced, blood glucose levels and leptin mRNA expression in the epididymal WAT were significantly decreased, serum leptin levels also tended to decrease, and serum adiponectin levels tended to increase. These results demonstrate that H. roretzi lipids have beneficial health effects on diabetic/obese KK-Ay mice.
Type: article
URI: http://hdl.handle.net/2115/45370
Appears in Collections:水産科学院・水産科学研究院 (Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 細川 雅史

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