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Pain may predict poor prognosis in patients with oral squamous cell carcinoma

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Title: Pain may predict poor prognosis in patients with oral squamous cell carcinoma
Authors: Sato, Jun Browse this author
Yamazaki, Yutaka Browse this author
Satoh, Akira Browse this author
Onodera-Kyan, Makiko Browse this author
Abe, Takahiro Browse this author
Satoh, Takehiko Browse this author
Notani, Ken-ichi Browse this author
Kitagawa, Yoshimasa Browse this author
Issue Date: May-2011
Publisher: Mosby
Journal Title: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology
Volume: 111
Issue: 5
Start Page: 587
End Page: 592
Publisher DOI: 10.1016/j.tripleo.2010.11.033
PMID: 21497734
Abstract: Objectives: We have previously reported that the histologic mode of invasion of oral squamous cell carcinoma (OSCC) is a significant risk factor for pain. We sought to determine whether pain is a risk factor for poor prognosis in patients with OSCC. Study Design: We evaluated the relationships between overall survival rates (OSRs) and clinicopathological variables, including gender, age, T- and N-stages, pathologic findings, and pain in 109 consecutive patients with untreated OSCC. Results: Of these 109 patients, 40 (37%) reported spontaneous pain. Univariate analysis showed that the OSR of patients with spontaneous pain was significantly lower than that of patients without pain (P = 0.002). Multivariate analysis revealed that spontaneous pain and N-stage were significant independent predictors of OSR. Conclusion: This is the first report showing that spontaneous pain before treatment may be associated with poor prognosis in patients with OSCC.
Type: article (author version)
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 佐藤 淳

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