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Effects of prenatal exposure to dioxin-like compounds on allergies and infections during infancy

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Title: Effects of prenatal exposure to dioxin-like compounds on allergies and infections during infancy
Authors: Miyashita, Chihiro Browse this author →KAKEN DB
Sasaki, Seiko Browse this author →KAKEN DB
Saijo, Yasuaki Browse this author →KAKEN DB
Washino, Noriaki Browse this author
Okada, Emiko Browse this author →KAKEN DB
Kobayashi, Sumitaka Browse this author →KAKEN DB
Konishi, Kanae Browse this author
Kajiwara, Jumboku Browse this author
Todaka, Takashi Browse this author
Kishi, Reiko Browse this author →KAKEN DB
Keywords: Dioxin-like compounds
Prenatal exposure
Issue Date: May-2011
Publisher: Elsevier
Journal Title: Environmental Research
Volume: 111
Issue: 4
Start Page: 551
End Page: 558
Publisher DOI: 10.1016/j.envres.2011.01.021
PMID: 21324443
Abstract: Dioxin-like compounds are endocrine disruptors. The effects of prenatal exposure to environmental levels of dioxins on immune function during infancy have not been clarified, although dioxins induce immunosuppression in offspring of animals. Moreover, human studies have not assessed the effects of gender- or congener-specific differences. The purpose of this study was to investigate the association between dioxin levels in maternal blood and the risk of infection and allergies in infancy. We examined 364 mothers and their infants enrolled in a Hokkaido Study on Environment and Children's Health between 2002 and 2005 in Sapporo, Japan. Relevant information was collected from a baseline questionnaire during pregnancy, medical records at delivery, and a follow-up questionnaire when the child was 18 months of age that assessed development of allergies and infections in infancy. Dioxin-like compound levels in maternal blood were measured with high-resolution gas chromatography/high-resolution mass spectrometry. Relatively higher levels of polychlorinated dibenzofuran were associated with a significantly increased risk of otitis media, especially among male infants (odds ratio=2.5, 95% confidence interval=1.1-5.9). Relatively higher levels of 2,3,4,7,8-pentachlorodibenzofuran were also associated with a significantly increased risk of otitis media (odds ratio=5.3, 95% confidence interval=1.5-19). However, we observed a weak association between dioxin-like compound levels and allergic symptoms in infancy. At environmental levels, prenatal exposure to dioxin-like compounds may alter immune function and increase the risk of infections in infancy, especially among males. The compound 2,3,4,7,8-pentachlorodibenzofuran may be responsible for this.
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 岸 玲子

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