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Macrophage migration inhibitory factor contributes to development of nonsteroidal anti-inflammatory drugs-induced gastric injury in mice

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Title: Macrophage migration inhibitory factor contributes to development of nonsteroidal anti-inflammatory drugs-induced gastric injury in mice
Authors: Ohkawara, Tatsuya Browse this author
Takeda, Hiroshi Browse this author
Ohnishi, Shunsuke Browse this author
Kato, Mototsugu Browse this author
Nishihira, Jun Browse this author
Asaka, Masahiro Browse this author
Keywords: Macrophage migration inhibitory factor
Gastric injury
Non-steroidal anti-inflammatory drugs
Issue Date: Apr-2011
Publisher: Elsevier B.V.
Journal Title: International Immunopharmacology
Volume: 11
Issue: 4
Start Page: 418
End Page: 423
Publisher DOI: 10.1016/j.intimp.2010.12.009
PMID: 21185918
Abstract: Macrophage migration inhibitory factor (MIF) plays an important role in the development of inflammation. In this study, we evaluated the role of MIF in gastric injury induced by non-steroidal anti-inflammatory drugs (NSAIDs) in mice. To induce gastric injury, mice were intraperitnoneally injected with 35 mg/kg of indomethacin. The level of MIF protein was up-regulated and severe gastric injury with inflammatory infiltrate was observed in the stomach of wild-type (WT) mice treated with indomethacin. The severity of gastric injury in MIF-deficient mice was less than that in WT mice. Increase in TNF-α in gastric tissue of mice treated with indomethacin was suppressed in MIF-deficient mice. The expression of HSP70, which has a cytoprotective role, was remarkably up-regulated in the stomach of MIF-deficient mice compared with WT mice after indomethacin treatment. Our results suggest that MIF is essential for the development of gastric injury-induced by NSAIDs.
Type: article (author version)
URI: http://hdl.handle.net/2115/45501
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 大川原 辰也

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