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Macrophage migration inhibitory factor contributes to development of nonsteroidal anti-inflammatory drugs-induced gastric injury in mice
Title: | Macrophage migration inhibitory factor contributes to development of nonsteroidal anti-inflammatory drugs-induced gastric injury in mice |
Authors: | Ohkawara, Tatsuya Browse this author | Takeda, Hiroshi Browse this author | Ohnishi, Shunsuke Browse this author | Kato, Mototsugu Browse this author | Nishihira, Jun Browse this author | Asaka, Masahiro Browse this author |
Keywords: | Macrophage migration inhibitory factor | Gastric injury | Non-steroidal anti-inflammatory drugs |
Issue Date: | Apr-2011 |
Publisher: | Elsevier B.V. |
Journal Title: | International Immunopharmacology |
Volume: | 11 |
Issue: | 4 |
Start Page: | 418 |
End Page: | 423 |
Publisher DOI: | 10.1016/j.intimp.2010.12.009 |
PMID: | 21185918 |
Abstract: | Macrophage migration inhibitory factor (MIF) plays an important role in the development of inflammation. In this study, we evaluated the role of MIF in gastric injury induced by non-steroidal anti-inflammatory drugs (NSAIDs) in mice. To induce gastric injury, mice were intraperitnoneally injected with 35 mg/kg of indomethacin. The level of MIF protein was up-regulated and severe gastric injury with inflammatory infiltrate was observed in the stomach of wild-type (WT) mice treated with indomethacin. The severity of gastric injury in MIF-deficient mice was less than that in WT mice. Increase in TNF-α in gastric tissue of mice treated with indomethacin was suppressed in MIF-deficient mice. The expression of HSP70, which has a cytoprotective role, was remarkably up-regulated in the stomach of MIF-deficient mice compared with WT mice after indomethacin treatment. Our results suggest that MIF is essential for the development of gastric injury-induced by NSAIDs. |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/45501 |
Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 大川原 辰也
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