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Imbalance between macrophage migration inhibitory factor and cortisol induces multiple organ dysfunction in patients with blunt trauma
| Title: | Imbalance between macrophage migration inhibitory factor and cortisol induces multiple organ dysfunction in patients with blunt trauma |
| Authors: | Hayakawa, Mineji Browse this author →KAKEN DB | | Katabami, Kenichi Browse this author | | Wada, Takeshi Browse this author →KAKEN DB | | Minami, Yousuke Browse this author | | Sugano, Masahiro Browse this author | | Shimojima, Hidekazu Browse this author | | Kubota, Nobuhiko Browse this author | | Uegaki, Shinji Browse this author | | Sawamura, Atsushi Browse this author →KAKEN DB | | Gando, Satoshi Browse this author |
| Keywords: | Glucocorticoids | | multiple organ failure | | multiple trauma | | tumor necrosis factor-alpha | | systemic inflammatory response syndrome |
| Issue Date: | Jun-2011 |
| Publisher: | Springer |
| Journal Title: | Inflammation |
| Volume: | 34 |
| Issue: | 3 |
| Start Page: | 193 |
| End Page: | 197 |
| Publisher DOI: | 10.1007/s10753-010-9223-2 |
| PMID: | 20499270 |
| Abstract: | Migration inhibitory factor (MIF) is associated with multiple organ dysfunction syndrome (MODS) in patients with systemic inflammatory response syndrome (SIRS). Our purposes were to determine the serum MIF, cortisol and tumor narcosis factor-α (TNF-α) and to investigate the influences of the balance between the levels of MIF and cortisol in patients with blunt trauma. The cortisol levels were identical between the patients with and without MODS. However, the MIF and TNF-α levels in the patients with MODS were statistically higher than those of the patients without MODS. The cortisol/MIF ratios in the patients with MODS were statistically higher than those of the patients without MODS. The results show that MIF and TNF-α play an important role together in post-traumatic inflammatory response. An excessive serum MIF elevation overrides the anti-inflammatory effects of cortisol and leads to persistent SIRS followed by MODS in blunt trauma patients. |
| Rights: | The originalpublication is available at www.springerlink.com |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/45532 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 早川 峰司
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