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Imbalance between macrophage migration inhibitory factor and cortisol induces multiple organ dysfunction in patients with blunt trauma

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/45532

Title: Imbalance between macrophage migration inhibitory factor and cortisol induces multiple organ dysfunction in patients with blunt trauma
Authors: Hayakawa, Mineji Browse this author →KAKEN DB
Katabami, Kenichi Browse this author
Wada, Takeshi Browse this author →KAKEN DB
Minami, Yousuke Browse this author
Sugano, Masahiro Browse this author
Shimojima, Hidekazu Browse this author
Kubota, Nobuhiko Browse this author
Uegaki, Shinji Browse this author
Sawamura, Atsushi Browse this author →KAKEN DB
Gando, Satoshi Browse this author
Keywords: Glucocorticoids
multiple organ failure
multiple trauma
tumor necrosis factor-alpha
systemic inflammatory response syndrome
Issue Date: Jun-2011
Publisher: Springer
Journal Title: Inflammation
Volume: 34
Issue: 3
Start Page: 193
End Page: 197
Publisher DOI: 10.1007/s10753-010-9223-2
PMID: 20499270
Abstract: Migration inhibitory factor (MIF) is associated with multiple organ dysfunction syndrome (MODS) in patients with systemic inflammatory response syndrome (SIRS). Our purposes were to determine the serum MIF, cortisol and tumor narcosis factor-α (TNF-α) and to investigate the influences of the balance between the levels of MIF and cortisol in patients with blunt trauma. The cortisol levels were identical between the patients with and without MODS. However, the MIF and TNF-α levels in the patients with MODS were statistically higher than those of the patients without MODS. The cortisol/MIF ratios in the patients with MODS were statistically higher than those of the patients without MODS. The results show that MIF and TNF-α play an important role together in post-traumatic inflammatory response. An excessive serum MIF elevation overrides the anti-inflammatory effects of cortisol and leads to persistent SIRS followed by MODS in blunt trauma patients.
Rights: The originalpublication is available at www.springerlink.com
Type: article (author version)
URI: http://hdl.handle.net/2115/45532
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 早川 峰司

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