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Immunomodulatory effect of mushrooms on cytotoxic activity and cytokine production of intestinal lamina propria leukocytes does not necessarily depend on β-glucan contents

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Title: Immunomodulatory effect of mushrooms on cytotoxic activity and cytokine production of intestinal lamina propria leukocytes does not necessarily depend on β-glucan contents
Authors: Lee, Jae-Sung Browse this author
Oka, Kohsuke Browse this author
Watanabe, Osamu Browse this author
Hara, Hiroshi Browse this author
Ishizuka, Satoshi Browse this author
Keywords: β-Glucan
Cytotoxicity
Intestine
Lamina propria leukocyte
Rat
Issue Date: 15-Jun-2011
Publisher: Elsevier
Journal Title: Food Chemistry
Volume: 126
Issue: 4
Start Page: 1521
End Page: 1526
Publisher DOI: 10.1016/j.foodchem.2010.12.063
PMID: 25213921
Abstract: We evaluated the effects of seven mushroom extracts (Grifola frondosa, Pholiota nameko, Panellus serotinus, Hypsizygus marmoreus, Pleurotus cornucopiae, Armillaria mellea, and Flammulina velutipes) on cytotoxic activity and cytokine production of lamina propria leukocytes (LPLs) isolated from rat small (S) and large (L) intestinal mucosa. Boiling water extracts from seven species of mushrooms showed no direct cytotoxicity against the YAC-1 target cells. However, prominent increases of cytotoxicity were observed in S- and L-LPLs co-cultured with P. serotinus extract. Cytokine production (TNFα, IFNγ, IL-12 p70, and IL-4) of S- and L-LPLs was stimulated in response to P. cornucopiae extract. Mushroom extracts contributed to target cell adhesion and/or cytokine production in the effector cells. The promotion of cytotoxic activity in S- and L-LPLs was not necessarily related to β-glucan content of the mushroom.
Type: article (author version)
URI: http://hdl.handle.net/2115/45764
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 石塚 敏

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