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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Agriculture / Faculty of Agriculture >
Peer-reviewed Journal Articles, etc >
Immunomodulatory effect of mushrooms on cytotoxic activity and cytokine production of intestinal lamina propria leukocytes does not necessarily depend on β-glucan contents
| Title: | Immunomodulatory effect of mushrooms on cytotoxic activity and cytokine production of intestinal lamina propria leukocytes does not necessarily depend on β-glucan contents |
| Authors: | Lee, Jae-Sung Browse this author | | Oka, Kohsuke Browse this author | | Watanabe, Osamu Browse this author | | Hara, Hiroshi Browse this author | | Ishizuka, Satoshi Browse this author |
| Keywords: | β-Glucan | | Cytotoxicity | | Intestine | | Lamina propria leukocyte | | Rat |
| Issue Date: | 15-Jun-2011 |
| Publisher: | Elsevier |
| Journal Title: | Food Chemistry |
| Volume: | 126 |
| Issue: | 4 |
| Start Page: | 1521 |
| End Page: | 1526 |
| Publisher DOI: | 10.1016/j.foodchem.2010.12.063 |
| PMID: | 25213921 |
| Abstract: | We evaluated the effects of seven mushroom extracts (Grifola frondosa, Pholiota nameko, Panellus serotinus, Hypsizygus marmoreus, Pleurotus cornucopiae, Armillaria mellea, and Flammulina velutipes) on cytotoxic activity and cytokine production of lamina propria leukocytes (LPLs) isolated from rat small (S) and large (L) intestinal mucosa. Boiling water extracts from seven species of mushrooms showed no direct cytotoxicity against the YAC-1 target cells. However, prominent increases of cytotoxicity were observed in S- and L-LPLs co-cultured with P. serotinus extract. Cytokine production (TNFα, IFNγ, IL-12 p70, and IL-4) of S- and L-LPLs was stimulated in response to P. cornucopiae extract. Mushroom extracts contributed to target cell adhesion and/or cytokine production in the effector cells. The promotion of cytotoxic activity in S- and L-LPLs was not necessarily related to β-glucan content of the mushroom. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/45764 |
| Appears in Collections: | 農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 石塚 敏
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