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Furazolidone induces the activity of microsomal enzymes that metabolize furazolidone in chickens

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Title: Furazolidone induces the activity of microsomal enzymes that metabolize furazolidone in chickens
Authors: Sasaki, Nobuo Browse this author
Matsumoto, Tomoyuki Browse this author
Ikenaka, Yoshinori Browse this author →KAKEN DB
Kazusaka, Akio Browse this author →KAKEN DB
Ishizuka, Mayumi Browse this author →KAKEN DB
Fujita, Shoichi Browse this author →KAKEN DB
Keywords: Chicken
Cytochrome P450
Furazolidone
Liver
NADPH cytochrome P450 reductase
Issue Date: Jun-2011
Publisher: Elsevier
Journal Title: Pesticide Biochemistry and Physiology
Volume: 100
Issue: 2
Start Page: 135
End Page: 139
Publisher DOI: 10.1016/j.pestbp.2011.02.013
Abstract: The nitrofuran antibacterial agent furazolidone (FZ) is still used in veterinary medicine in some countries in the Middle and Far East. The present study aimed to show the effect of FZ on the activity of microsomal enzymes that metabolize FZ, and to identify the enzyme that contributes to FZ metabolism in chickens. Wistar rats and White Leghorn chickens were administered FZ once a day for 4 consecutive days. FZ metabolism was accelerated by FZ administration in chickens, but not in rats. The elevation of FZ metabolism coincided with the induction of NADPH cytochrome P450 reductase (CPR) activity in chickens, but such induction was not observed in rats. FZ metabolizing activities were inhibited in the presence of a CPR inhibitor (diphenylene iodonium chloride) but not by the addition of archetypal cytochrome P450 inhibitors (CO or n-octylamine). The preset study concluded that FZ accelerated its own metabolism in the chicken by induction of the activity of CPR.
Type: article (author version)
URI: http://hdl.handle.net/2115/45809
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 石塚 真由美

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