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Heterogeneous Reduction of Myocardial Oxidative Metabolism in Patients With Ischemic and Dilated Cardiomyopathy Using C-11 Acetate PET

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Title: Heterogeneous Reduction of Myocardial Oxidative Metabolism in Patients With Ischemic and Dilated Cardiomyopathy Using C-11 Acetate PET
Authors: Wu, Yen-Wen Browse this author
Naya, Masanao Browse this author
Tsukamoto, Takahiro Browse this author
Komatsu, Hiroshi Browse this author
Morita, Koichi Browse this author
Yoshinaga, Keiichiro Browse this author
Kuge, Yuji Browse this author
Tsutsui, Hiroyuki Browse this author
Tamaki, Nagara Browse this author
Keywords: Carbon-11 acetate PET
Dilated cardiomyopathy
Ischemic cardiomyopathy
Left ventricular dysfunction
Myocardial oxidative metabolism
Issue Date: 2008
Publisher: 日本循環器学会
Journal Title: Circulation Journal
Volume: 72
Issue: 5
Start Page: 786
End Page: 792
Publisher DOI: 10.1253/circj.72.786
Abstract: Background :The 11C-acetate positron emission tomography can estimate myocardial oxidative metabolism, but previous studies have only evaluated small populations and the difference between ischemic (ICM) and idiopathic dilated cardiomyopathy (DCM) has not been fully investigated. The present aims were to evaluate global and regional myocardial oxidative metabolism in a well-characterized, large population with left ventricular (LV) dysfunction in order to clarify the metabolic differences between ICM and DCM. Methods and Results :Seventy-eight patients with ejection fraction (EF) ≤50% (33 ICM; 45 DCM) were compared with 14 healthy controls. Myocardial oxidative metabolism was estimated with a clearance rate constant (Kmono) and the coefficient of variation (CV) of regional Kmono. Patients with LV dysfunction had reduced Kmono and higher CV (p<0.05). In the comparison of oxidative alterations with clinical variables there was a weak correlation between Kmono and LVEF (r=0.27). Although Kmono was reduced in both ICM and DCM, CV was more pronouncedly increased in ICM (p=0.001). In multivariate analysis, the presence of left bundle branch block (LBBB) was an independent predictor of heterogeneous oxidative metabolism in DCM (R2=0.30, p<0.0001). Conclusions :Global reduction of myocardial oxidative metabolism occurred in both ICM and DCM. Heterogeneous oxidative metabolism was observed in these patients, especially those with ICM. Furthermore, LBBB was the independent predictor of heterogeneous oxidative metabolism in patients with DCM. (Circ J 2008; 72: 786 - 792)
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 玉木 長良

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