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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >
Elevated Plasma Plasminogen Activator Inhibitor Type-1 is an Independent Predictor of Coronary Microvascular Dysfunction in Hypertension
| Title: | Elevated Plasma Plasminogen Activator Inhibitor Type-1 is an Independent Predictor of Coronary Microvascular Dysfunction in Hypertension |
| Authors: | Naya, Masanao Browse this author | | Tsukamoto, Takahiro Browse this author | | Inubushi, Masayuki Browse this author | | Morita, Koichi Browse this author | | Katoh, Chietsugu Browse this author | | Furumoto, Tomoo Browse this author | | Fujii, Satoshi Browse this author | | Tsutsui, Hiroyuki Browse this author | | Tamaki, Nagara Browse this author →KAKEN DB |
| Keywords: | Coronary circulation | | Fibrinolysis | | Hypertension | | Plasminogen activator inhibitor type-1 | | Positron emission tomography |
| Issue Date: | 2007 |
| Publisher: | 日本循環器学会 |
| Journal Title: | Circulation Journal |
| Volume: | 71 |
| Issue: | 3 |
| Start Page: | 348 |
| End Page: | 353 |
| Publisher DOI: | 10.1253/circj.71.348 |
| Abstract: | Background :Elevated plasma plasminogen activator inhibitor-1 (PAI-1) is related to cardiovascular events, but its role in subclinical coronary microvascular dysfunction remains unknown. Thus, in the present study it was investigated whether elevated plasma PAI-1 activity is associated with coronary microvascular dysfunction in hypertensive patients. Methods and Results :Thirty patients with untreated essential hypertension and 10 age-matched healthy controls were studied prospectively. Myocardial blood flow (MBF) was measured by using 15O-water positron emission tomography. Clinical variables associated with atherosclerosis (low-density lipoprotein-cholesterol, high-density lipoprotein (HDL)-cholesterol, triglyceride, homeostasis model assessment (HOMA-IR), and PAI-1 activity) were assessed to determine their involvement in coronary microvascular dysfunction. Adenosine triphosphate (ATP)-induced hyperemic MBF and coronary flow reserve (CFR) were significantly lower in hypertensive patients than in healthy controls (ATP-induced MBF: 2.77±0.82 vs 3.49±0.71 ml · g-1 · min-1; p<0.02 and CFR: 2.95 ±1.06 vs 4.25±0.69; p<0.001). By univariate analysis, CFR was positively correlated with HDL-cholesterol (r=0.46, p<0.02), and inversely with HOMA-IR (r=-0.39, p<0.05) and PAI-1 activity (r=-0.61, p<0.001). By multivariate analysis, elevated PAI-1 activity remained a significant independent determinant of diminished CFR. Conclusions :Elevated plasma PAI-1 activity was independently associated with coronary microvascular dysfunction, which suggests that plasma PAI-1 activity is an important clue linking hypofibrinolysis to the development of atherosclerosis. (Circ J 2007; 71: 348 - 353) |
| Type: | article |
| URI: | http://hdl.handle.net/2115/45965 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 玉木 長良
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