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Repeatability of Rest and Hyperemic Myocardial Blood Flow Measurements with 82Rb Dynamic PET

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Title: Repeatability of Rest and Hyperemic Myocardial Blood Flow Measurements with 82Rb Dynamic PET
Authors: Manabe, Osamu Browse this author
Yoshinaga, Keiichiro Browse this author
Katoh, Chietsugu Browse this author
Naya, Masanao Browse this author
deKemp, Robert A. Browse this author
Tamaki, Nagara Browse this author →KAKEN DB
Keywords: myocardial blood flow
pharmacologic stress
82Rb
Issue Date: 2009
Publisher: Society of Nuclear Medicine
Journal Title: Journal of Nuclear Medicine
Volume: 50
Issue: 1
Start Page: 68
End Page: 71
Publisher DOI: 10.2967/jnumed.108.055673
PMID: 19091892
Abstract: The repeatability of rest and hyperemic myocardial blood flow (MBF) measurements using 82Rb PET has not been evaluated. The aimof this study was to investigate the short-term repeatability of such measurements. Methods: Fifteen healthy volunteers underwent rest and pharmacologic stress 82Rb PET, repeated 60 min apart. Results: There was no significant difference in repeated rest MBF (0.77 6 0.25 vs. 0.82 6 0.25 mL/min/g, P 5 0.31; mean difference, 6.18% 6 12.22%) or repeated hyperemic MBF (3.35 6 1.37 vs. 3.39 6 1.37 mL/min/g, P 5 0.81; mean difference, 1.17% 6 13.64%). The repeatability coefficients were 0.19 mL/min/g for rest MBF and 0.92 mL/min/g for hyperemia. Conclusion:MBF using 82Rb is highly reproducible using a sameday short-term repeatability protocol. Serial MBF measurements with 82Rb PET should have the ability to quantify the acute effects of therapeutic interventions on MBF.
Rights: Reprinted by permission of the Society of Nuclear Medicine
Type: article
URI: http://hdl.handle.net/2115/46752
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 玉木 長良

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