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Myocardial  beta-Adrenergic Receptor Density Assessed by 11C-CGP12177 PET Predicts Improvement of Cardiac Function After Carvedilol Treatment in Patients with Idiopathic Dilated Cardiomyopathy

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Title: Myocardial  beta-Adrenergic Receptor Density Assessed by 11C-CGP12177 PET Predicts Improvement of Cardiac Function After Carvedilol Treatment in Patients with Idiopathic Dilated Cardiomyopathy
Authors: Naya, Masanao Browse this author
Tsukamoto, Takahiro Browse this author
Morita, Koichi Browse this author
Katoh, Chietsugu Browse this author
Nishijima, Kenichi Browse this author
Komatsu, Hiroshi Browse this author
Yamada, Satoshi Browse this author
Kuge, Yuji Browse this author
Tamaki, Nagara Browse this author →KAKEN DB
Tsutsui, Hiroyuki Browse this author
Keywords: b-adrenergic receptor
carvedilol
11C-CGP12177PET
heart failure
Issue Date: 2009
Publisher: Society of Nuclear Medicine
Journal Title: Journal of Nuclear Medicine
Volume: 50
Issue: 2
Start Page: 220
End Page: 225
Publisher DOI: 10.2967/jnumed.108.056341
PMID: 19164238
Abstract: We evaluated whether myocardial b-adrenergic receptor (b-AR) density, as determined by 11C-CGP12177 PET, could predict improvement of cardiac function by b-blocker carvedilol treatment in patients with idiopathic dilated cardiomyopathy (IDC). Methods: Ten patients with IDC (left ventricular ejection fraction [LVEF] , 45%) were studied. Myocardial b-AR density was estimated using 11C-CGP12177 PET before treatment with carvedilol. Changes of LVEF in response to dobutamine infusion (DLVEF-dobutamine) were also measured by echocardiography. Changes of LVEF (DLVEF-carvedilol) were evaluated after 20 mo of carvedilol treatment. Results: Baseline myocardial b-AR density significantly correlated with DLVEF-carvedilol (r 5 20.88, P , 0.001). In contrast, DLVEF-dobutamine did not correlate with DLVEF-carvedilol (P50.65).Myocardial b-ARdensitywas the significant multivariate independent predictor of DLVEF-carvedilol (b 5 20.88, P , 0.001) among univariate predictors, including functional class (r 5 0.76, P , 0.05), plasma norepinephrine (r 5 0.85, P,0.01), LVEF (r520.64, P,0.05), and age as confounding factors. Furthermore, myocardial b-AR density was significantly correlated with plasma norepinephrine (r 5 20.79, P , 0.01) and LVEF (r 5 0.70, P , 0.05). Conclusion: Myocardial b-AR density is more tightly related to improvement of LVEFcarvedilol than is cardiac contractile reserve in patients with IDC. Patients with decreased myocardial b-AR have higher resting adrenergic drive, as reflected by plasma norepinephrine, and may receive greater benefit from being treated by antiadrenergic drugs.
Rights: Reprinted by permission of the Society of Nuclear Medicine
Type: article
URI: http://hdl.handle.net/2115/46754
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 玉木 長良

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