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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >
Myocardial beta-Adrenergic Receptor Density Assessed by 11C-CGP12177 PET Predicts Improvement of Cardiac Function After Carvedilol Treatment in Patients with Idiopathic Dilated Cardiomyopathy
| Title: | Myocardial beta-Adrenergic Receptor Density Assessed by 11C-CGP12177 PET Predicts Improvement of Cardiac Function After Carvedilol Treatment in Patients with Idiopathic Dilated Cardiomyopathy |
| Authors: | Naya, Masanao Browse this author | | Tsukamoto, Takahiro Browse this author | | Morita, Koichi Browse this author | | Katoh, Chietsugu Browse this author | | Nishijima, Kenichi Browse this author | | Komatsu, Hiroshi Browse this author | | Yamada, Satoshi Browse this author | | Kuge, Yuji Browse this author | | Tamaki, Nagara Browse this author →KAKEN DB | | Tsutsui, Hiroyuki Browse this author |
| Keywords: | b-adrenergic receptor | | carvedilol | | 11C-CGP12177PET | | heart failure |
| Issue Date: | 2009 |
| Publisher: | Society of Nuclear Medicine |
| Journal Title: | Journal of Nuclear Medicine |
| Volume: | 50 |
| Issue: | 2 |
| Start Page: | 220 |
| End Page: | 225 |
| Publisher DOI: | 10.2967/jnumed.108.056341 |
| PMID: | 19164238 |
| Abstract: | We evaluated whether myocardial b-adrenergic receptor (b-AR) density, as determined by 11C-CGP12177 PET, could predict improvement of cardiac function by b-blocker carvedilol treatment in patients with idiopathic dilated cardiomyopathy (IDC). Methods: Ten patients with IDC (left ventricular ejection fraction [LVEF] , 45%) were studied. Myocardial b-AR density was estimated using 11C-CGP12177 PET before treatment with carvedilol. Changes of LVEF in response to dobutamine infusion (DLVEF-dobutamine) were also measured by echocardiography. Changes of LVEF (DLVEF-carvedilol) were evaluated after 20 mo of carvedilol treatment. Results: Baseline myocardial b-AR density significantly correlated with DLVEF-carvedilol (r 5 20.88, P , 0.001). In contrast, DLVEF-dobutamine did not correlate with DLVEF-carvedilol (P50.65).Myocardial b-ARdensitywas the significant multivariate independent predictor of DLVEF-carvedilol (b 5 20.88, P , 0.001) among univariate predictors, including functional class (r 5 0.76, P , 0.05), plasma norepinephrine (r 5 0.85, P,0.01), LVEF (r520.64, P,0.05), and age as confounding factors. Furthermore, myocardial b-AR density was significantly correlated with plasma norepinephrine (r 5 20.79, P , 0.01) and LVEF (r 5 0.70, P , 0.05). Conclusion: Myocardial b-AR density is more tightly related to improvement of LVEFcarvedilol than is cardiac contractile reserve in patients with IDC. Patients with decreased myocardial b-AR have higher resting adrenergic drive, as reflected by plasma norepinephrine, and may receive greater benefit from being treated by antiadrenergic drugs. |
| Rights: | Reprinted by permission of the Society of Nuclear Medicine |
| Type: | article |
| URI: | http://hdl.handle.net/2115/46754 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 玉木 長良
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