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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine >
Peer-reviewed Journal Articles, etc >
Overexpression of interferon-activated gene 202 (Ifi202) correlates with the progression of autoimmune glomerulonephritis associated with the MRL chromosome 1
| Title: | Overexpression of interferon-activated gene 202 (Ifi202) correlates with the progression of autoimmune glomerulonephritis associated with the MRL chromosome 1 |
| Authors: | Ichii, Osamu Browse this author →KAKEN DB | | Kamikawa, Akihiro Browse this author | | Otsuka, Saori Browse this author →KAKEN DB | | Hashimoto, Yoshiharu Browse this author →KAKEN DB | | Sasaki, Nobuya Browse this author →KAKEN DB | | Endoh, Daiji Browse this author | | Kon, Yasuhiro Browse this author →KAKEN DB |
| Keywords: | autoimmune glomerulonephritis | | interferon activated gene 202 | | kidney | | lupus nephritis | | MRL congenic mouse |
| Issue Date: | Jul-2010 |
| Publisher: | SAGE Publications |
| Journal Title: | Lupus |
| Volume: | 19 |
| Issue: | 8 |
| Start Page: | 897 |
| End Page: | 905 |
| Publisher DOI: | 10.1177/0961203310362534 |
| PMID: | 20167632 |
| Abstract: | B6.MRLc1(82-100) congenic mice carrying the telomeric region of lupus-prone MRL chromosome 1 develop autoimmune glomerulonephritis (GN). The GN susceptibility locus of B6.MRLc1(82-100) contains the interferon activated gene 200 (Ifi200) family, which consists of Ifi202, 203, 204, and 205. Recently, Ifi202 was suggested as a candidate gene for murine lupus. In this study, we assessed the association between Ifi200 family and GN in several disease models. We compared the expression of Ifi200 family members in 24 organs between the C57BL/6 and B6.MRLc1(82-100). The expressions of Ifi200 family members differed between strains, especially, the most dramatic differences appeared in Ifi202 expression. Briefly, in the blood, immune organs, lungs, and testes was higher in B6.MRLc1(82-100) mice. In the kidney and immune organs, only Ifi202 expression increased with the development of GN in B6.MRLc1(82-100), and significant differences from C57BL/6 were observed even before disease onset. Ifi202 expression in the kidneys of BXSB, NZB/WF1, and MRL/lpr was also significantly high in the early- and late-disease stages. Furthermore, laser microdissection-RT-PCR analysis confirmed the high Ifi202 expression in all areas of B6.MRLc1(82-100) kidneys. In conclusion, among Ifi200 family, Ifi202 expressions in the kidney and immune organs significantly increased with GN progression. |
| Rights: | The final, definitive version of this article has been published in the Journal, Lupus, 19(8), 2010 of publication, © SAGE Publications Ltd, 2010 by SAGE Publications Ltd at the Lupus page: http://lup.sagepub.com/ on SAGE Journals Online: http://online.sagepub.com/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/46758 |
| Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 市居 修
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