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Overexpression of interferon-activated gene 202 (Ifi202) correlates with the progression of autoimmune glomerulonephritis associated with the MRL chromosome 1

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Title: Overexpression of interferon-activated gene 202 (Ifi202) correlates with the progression of autoimmune glomerulonephritis associated with the MRL chromosome 1
Authors: Ichii, Osamu Browse this author →KAKEN DB
Kamikawa, Akihiro Browse this author
Otsuka, Saori Browse this author →KAKEN DB
Hashimoto, Yoshiharu Browse this author →KAKEN DB
Sasaki, Nobuya Browse this author →KAKEN DB
Endoh, Daiji Browse this author
Kon, Yasuhiro Browse this author →KAKEN DB
Keywords: autoimmune glomerulonephritis
interferon activated gene 202
lupus nephritis
MRL congenic mouse
Issue Date: Jul-2010
Publisher: SAGE Publications
Journal Title: Lupus
Volume: 19
Issue: 8
Start Page: 897
End Page: 905
Publisher DOI: 10.1177/0961203310362534
PMID: 20167632
Abstract: B6.MRLc1(82-100) congenic mice carrying the telomeric region of lupus-prone MRL chromosome 1 develop autoimmune glomerulonephritis (GN). The GN susceptibility locus of B6.MRLc1(82-100) contains the interferon activated gene 200 (Ifi200) family, which consists of Ifi202, 203, 204, and 205. Recently, Ifi202 was suggested as a candidate gene for murine lupus. In this study, we assessed the association between Ifi200 family and GN in several disease models. We compared the expression of Ifi200 family members in 24 organs between the C57BL/6 and B6.MRLc1(82-100). The expressions of Ifi200 family members differed between strains, especially, the most dramatic differences appeared in Ifi202 expression. Briefly, in the blood, immune organs, lungs, and testes was higher in B6.MRLc1(82-100) mice. In the kidney and immune organs, only Ifi202 expression increased with the development of GN in B6.MRLc1(82-100), and significant differences from C57BL/6 were observed even before disease onset. Ifi202 expression in the kidneys of BXSB, NZB/WF1, and MRL/lpr was also significantly high in the early- and late-disease stages. Furthermore, laser microdissection-RT-PCR analysis confirmed the high Ifi202 expression in all areas of B6.MRLc1(82-100) kidneys. In conclusion, among Ifi200 family, Ifi202 expressions in the kidney and immune organs significantly increased with GN progression.
Rights: The final, definitive version of this article has been published in the Journal, Lupus, 19(8), 2010 of publication, © SAGE Publications Ltd, 2010 by SAGE Publications Ltd at the Lupus page: on SAGE Journals Online:
Type: article (author version)
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 市居 修

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