Title: | ZAPS is a potent stimulator of signaling mediated by the RNA helicase RIG-I during antiviral responses |
Authors: | Hayakawa, Sumio Browse this author |
Shiratori, Souichi Browse this author |
Yamato, Hiroaki Browse this author |
Kameyama, Takeshi Browse this author |
Kitatsuji, Chihiro Browse this author |
Kashigi, Fumi Browse this author |
Goto, Showhey Browse this author |
Kameoka, Shoichiro Browse this author |
Fujikura, Daisuke Browse this author |
Yamada, Taisho Browse this author |
Mizutani, Tatsuaki Browse this author |
Kazumata, Mika Browse this author |
Sato, Maiko Browse this author |
Tanaka, Junji Browse this author |
Asaka, Masahiro Browse this author |
Ohba, Yusuke Browse this author |
Miyazaki, Tadaaki Browse this author →KAKEN DB |
Imamura, Masahiro Browse this author |
Takaoka, Akinori Browse this author |
Issue Date: | Jan-2011 |
Publisher: | Nature Publishing Group |
Journal Title: | Nature Immunology |
Volume: | 12 |
Issue: | 1 |
Start Page: | 37 |
End Page: | 44 |
Publisher DOI: | 10.1038/ni.1963 |
PMID: | 21102435 |
Abstract: | The poly(ADP-ribose) polymerases (PARPs) participate in various processes. Here, we report that the PARP-13/ZAP shorter isoform (hereafter called ZAPS), rather than the full length protein, is selectively induced by 3pRNA, and functions as a potent stimulator of retinoic acid-inducible gene-I (RIG-I)-mediated interferon (IFN) responses in human cells. ZAPS associates with RIG-I to promote the oligomerization and ATPase activity of RIG-I, leading to robust activation of IRF3 and NF-κB pathways. Disruption of the PARP-13/ZAP gene, ZC3HAV1, severely abrogated the induction of IFN-α, IFN-β and other cytokines upon viral infection. These results indicate that ZAPS is a key regulator of RIG-I signaling during the innate antiviral immune response, suggesting its possible use as a therapeutic target for viral control. |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/46762 |
Appears in Collections: | 遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|