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Cytoplasmic expression of CD133 is an important risk factor for overall survival in hepatocellular carcinoma

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Title: Cytoplasmic expression of CD133 is an important risk factor for overall survival in hepatocellular carcinoma
Authors: Sasaki, Ayami Browse this author
Kamiyama, Toshiya Browse this author
Yokoo, Hideki Browse this author
Nakanishi, Kazuaki Browse this author
Kubota, Kanako Browse this author
Haga, Hironori Browse this author
Matsushita, Michiaki Browse this author
Ozaki, Michitaka Browse this author
Matsuno, Yoshihiro Browse this author
Todo, Satoru Browse this author
Keywords: CD133
cytoplasmic expression
hepatocellular carcinoma
Issue Date: Aug-2010
Publisher: Spandidos Publications
Journal Title: Oncology Reports
Volume: 24
Issue: 2
Start Page: 537
End Page: 546
Publisher DOI: 10.3892/or_00000890
Abstract: CD133 antigen has been used to identify cancer stem cells in several solid tumor types, including hepato-cellular carcinomas (HCCs). The aim of this study was to investigate whether the expression and subcellular localization of CD133 correlated with the clinicopathological factors, recurrence, and survival in HCC patients. Tissue specimens from 136 HCC patients who underwent curative primary hepatectomy between 2000 and 2005 were collected and immunohistochemically analyzed for CD133 expression. Positive immunohistochemical results and subcellular localization of CD133 were determined, and the correlation between CD133 expression and clinicopathological factors of HCC patients were evaluated. CD133-positive tumor cells were observed in 30 (22.1%) cases. Cytoplasmic and membranous expressions were observed in 22 (16.2%) and 20 (14.7%) of the CD133-positive cases, respectively. Positive cytoplasmic expression of CD133 was found to be associated with the overall survival of HCC patients, especially in stage III and IVA HCC patients (p=0.0092). Univariate analysis revealed that pre-operative serum albumin, α-fetoprotein (AFP) levels, tumor size, portal venous invasion, and cytoplasmic CD133 expression were important risk factors in HCC. Multivariate analysis revealed that among the factors related to tumor aggressiveness, cytoplasmic expression of CD133 showed the most significant association with overall survival, although the difference was not statistically significant (P=0.0681). Cytoplasmic expression of CD133 was a significant risk factor for the overall survival of HCC patients. Patients with stage III and IVA HCC showing positive cytoplasmic expression of CD133 are more likely to have a worse prognosis.
Type: article
URI: http://hdl.handle.net/2115/46865
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 藤堂 省

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