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High Prevalence of Multiple Human Papillomavirus Infection in Japanese Patients with Invasive Uterine Cervical Cancer

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Title: High Prevalence of Multiple Human Papillomavirus Infection in Japanese Patients with Invasive Uterine Cervical Cancer
Authors: Watari, Hidemichi Browse this author
Michimata, Rie Browse this author
Yasuda, Motoaki Browse this author →KAKEN DB
Ishizu, Akihiro Browse this author →KAKEN DB
Tomaru, Utano Browse this author →KAKEN DB
Xiong, Ying Browse this author
Hassan, Mohamed K. Browse this author
Sakuragi, Noriaki Browse this author →KAKEN DB
Keywords: Human papillomavirus, multiple infection
Cervix uteri
Array technology
Issue Date: Jul-2011
Publisher: Karger
Journal Title: Pathobiology
Volume: 78
Issue: 4
Start Page: 220
End Page: 226
Publisher DOI: 10.1159/000326770
PMID: 21778789
Abstract: Objective: Multiple human papillomavirus (HPV) infection of the uterine cervix has been suggested as a risk factor for persistent HPV infection, resulting in the development of invasive cervical cancer. The aim of this study was to reveal the actual state of multiple HPV infection in Japanese patients with invasive cervical cancer. Methods: Freshly-frozen 60 invasive cervical cancer tissues were examined for genotyping of HPV. The presence of HPV genotypes in the cancer tissues was determined by an HPV-DNA array, which can discriminate 25 different HPV genotypes with high sensitivity and specificity. Results: Among 60 samples, 59 (96.7%) were positive for HPV. The three common genotypes were HPV-16 (83.3%), HPV-18 (45.0%) and HPV-52 (28.3%). Multiple HPV infection was observed in 47 of 60 samples (78.3%), in which 42 cases were infected with more than one high-risk genotypes (70.0%). The multiple high-risk HPV infection was significantly more prevalent in patients below 40 years old (14/15, 93.3%) than in patients 40 years and over (28/45, 62.2%). Conclusion: The HPV-DNA array is the preferable method to detect HPV genotypes. Multiple HPV infection in Japanese patients with invasive cervical cancer seemed to be more frequent than reported in the literature.
Rights: Copyright © 2011 S. Karger AG, Basel
Type: article (author version)
URI: http://hdl.handle.net/2115/46895
Appears in Collections:保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 石津 明洋

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