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Volume 32, Number 2 >

IMMUNOHISTOCHEMICAL STUDIES ON THE LOCALIZATION OF ANTIGEN-BEARING PHAGOCYTES AND LYMPHOCYTES IN MOUSE LYMPH NODES AFTER THE GERMINAL CENTER FORMATION

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Please use this identifier to cite or link to this item:http://doi.org/10.14943/jjvr.32.2.73

Title: IMMUNOHISTOCHEMICAL STUDIES ON THE LOCALIZATION OF ANTIGEN-BEARING PHAGOCYTES AND LYMPHOCYTES IN MOUSE LYMPH NODES AFTER THE GERMINAL CENTER FORMATION
Authors: NAKAMURA, Kazuichi Browse this author
HASHIMOTO, Yoshiharu Browse this author
KITAGAWA, Hiroshi Browse this author
KUDO, Norio Browse this author
Keywords: antigen-bearing phagocytes
lymphocytes
germinal centers
mouse lymph nodes
Issue Date: 28-Apr-1984
Publisher: The Graduate School of Veterinary Medicine
Journal Title: Japanese Journal of Veterinary Research
Volume: 32
Issue: 2
Start Page: 73
End Page: 81
Abstract: The antigen, 2,4-dinitrophenylated and alumprecipitated bovine serum albumin, was inoculated into the foot pads at 2 weeks after the primary inoculation of the antigen. At 2 and 3 days after the second inoculation, many anti-T cell serum negative lymphocytes, possibly B cells, were found in the lumen and the endothelium of the post capillary venules, and they predominantly gathered around the venules. These gathering areas of possibly B cells were encountered frequently in contact with the cortical lymphatic nodules containing the germinal centers. From 4 to 14 days after the second inoculation, a number of antigen-bearing phagocytes appeared in the cortical marginal zones, which were located between the germinal centers and the marginal sinuses. These findings suggest that B cells are largely recruited from the blood to the paracortex, and also the antigen-bearing phagocytes directly present the antigen to the cortical lymphocytes for the acceleration of the antibody production after the formation of the germinal centers.
Type: bulletin (article)
URI: http://hdl.handle.net/2115/4694
Appears in Collections:Japanese Journal of Veterinary Research > Volume 32, Number 2

Submitter: 獣医学部図書室

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