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Distinctive and critical roles for cellular immunity and immune-inflammatory response in the immunopathology of Sendai virus infection in mice

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Title: Distinctive and critical roles for cellular immunity and immune-inflammatory response in the immunopathology of Sendai virus infection in mice
Authors: Simon, Ayo Yila Browse this author
Sasaki, Nobuya Browse this author →KAKEN DB
Ichii, Osamu Browse this author →KAKEN DB
Kajino, Kiichi Browse this author →KAKEN DB
Kon, Yasuhiro Browse this author →KAKEN DB
Agui, Takashi Browse this author →KAKEN DB
Keywords: Cellular immunity
Immune-inflammatory response
Gene expression analysis
Immunopathology
Sendai virus (HVJ)
Inbred mouse
Issue Date: Aug-2011
Publisher: Elsevier Masson SAS
Journal Title: Microbes and Infection
Volume: 13
Issue: 8-9
Start Page: 783
End Page: 797
Publisher DOI: 10.1016/j.micinf.2011.04.003
PMID: 21530676
Abstract: Respiratory viral infections result in severe pulmonary injury, to which host immune response may be a significant contributor. At present, it is not entirely clear the extent to which lung injury is a necessary consequence of host defense. In this report, we use functional genomics approach to characterize the key roles of cellular immunity and immune-inflammatory response in the immunopathology of Sendai virus infection in resistant C57BL/6J and susceptible DBA/2J mice. Infected mice manifested an immune-inflammatory response characterized by the pulmonary influx of neutrophils and mononuclear cells. DBA/2J mice mounted a vigorous immune response, with significant up-regulation of cytokine/chemokine genes in two successive waves through the course of infection. Whereas, C57BL/6J mice displayed an efficient immune response with less severe pathology and clusters of immune-inflammatory responsive genes were exclusively up-regulated on day 4 in this strain. Overall, DBA/2J mice exhibited a dysregulated hyper-inflammatory cytokine/chemokine cascades that does not limit viral spread resulting in a predisposition to severe lung pathology. This response is similar to severe human respiratory paramyxovirus infections, which will serve as a model for the elucidation of hyper-immune inflammatory response that result to severe immunopathology in respiratory viral infections.
Type: article (author version)
URI: http://hdl.handle.net/2115/46940
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 安居院 高志

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