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Hokkaido University Collection of Scholarly and Academic Papers >
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Distinctive and critical roles for cellular immunity and immune-inflammatory response in the immunopathology of Sendai virus infection in mice
| Title: | Distinctive and critical roles for cellular immunity and immune-inflammatory response in the immunopathology of Sendai virus infection in mice |
| Authors: | Simon, Ayo Yila Browse this author | | Sasaki, Nobuya Browse this author →KAKEN DB | | Ichii, Osamu Browse this author →KAKEN DB | | Kajino, Kiichi Browse this author →KAKEN DB | | Kon, Yasuhiro Browse this author →KAKEN DB | | Agui, Takashi Browse this author →KAKEN DB |
| Keywords: | Cellular immunity | | Immune-inflammatory response | | Gene expression analysis | | Immunopathology | | Sendai virus (HVJ) | | Inbred mouse |
| Issue Date: | Aug-2011 |
| Publisher: | Elsevier Masson SAS |
| Journal Title: | Microbes and Infection |
| Volume: | 13 |
| Issue: | 8-9 |
| Start Page: | 783 |
| End Page: | 797 |
| Publisher DOI: | 10.1016/j.micinf.2011.04.003 |
| PMID: | 21530676 |
| Abstract: | Respiratory viral infections result in severe pulmonary injury, to which host immune response may be a significant contributor. At present, it is not entirely clear the extent to which lung injury is a necessary consequence of host defense. In this report, we use functional genomics approach to characterize the key roles of cellular immunity and immune-inflammatory response in the immunopathology of Sendai virus infection in resistant C57BL/6J and susceptible DBA/2J mice. Infected mice manifested an immune-inflammatory response characterized by the pulmonary influx of neutrophils and mononuclear cells. DBA/2J mice mounted a vigorous immune response, with significant up-regulation of cytokine/chemokine genes in two successive waves through the course of infection. Whereas, C57BL/6J mice displayed an efficient immune response with less severe pathology and clusters of immune-inflammatory responsive genes were exclusively up-regulated on day 4 in this strain. Overall, DBA/2J mice exhibited a dysregulated hyper-inflammatory cytokine/chemokine cascades that does not limit viral spread resulting in a predisposition to severe lung pathology. This response is similar to severe human respiratory paramyxovirus infections, which will serve as a model for the elucidation of hyper-immune inflammatory response that result to severe immunopathology in respiratory viral infections. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/46940 |
| Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 安居院 高志
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