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Flavivirus Encephalitis : Pathological Aspects of Mouse and Other Animal Models

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Title: Flavivirus Encephalitis : Pathological Aspects of Mouse and Other Animal Models
Authors: Kimura, T. Browse this author →KAKEN DB
Sasaki, M. Browse this author
Okumura, M. Browse this author
Kim, E. Browse this author
Sawa, H. Browse this author
Keywords: experimental animal models
Japanese encephalitis virus
mosquito-borne encephalitis
West Nile virus
Issue Date: Sep-2010
Publisher: Sage Publications
Journal Title: Veterinary Pathology
Volume: 47
Issue: 5
Start Page: 806
End Page: 818
Publisher DOI: 10.1177/0300985810372507
PMID: 20551474
Abstract: Encephalitic flaviviruses are important arthropod-borne pathogens of humans and other animals. In particular, the recent emergence of the West Nile virus (WNV) and Japanese encephalitis virus (JEV) in new geographic areas has caused a considerable public health alert and international concern. Among the experimental in vivo models of WNV and JEV infection, mice and other laboratory rodents are the most thoroughly studied and well-characterized systems, having provided data that are important for understanding the infectious process in humans. Macaca monkeys have also been used as a model for WNV and JEV infection, mainly for the evaluation of vaccine efficacy, whereas a limited number of published studies address pathomorphology. These animal models develop encephalitis with many similarities to the human disease; however, the histological events that occur during infection, especially in peripheral tissues, have not been fully characterized.
Rights: The final, definitive version of this article has been published in the Journal, Veterinary Pathology, 47/5, 2010 of publication, © American College of Veterinary Pathologists, 2010 by SAGE Publications Ltd at the Veterinary Pathology page: on SAGE Journals Online:
Type: article (author version)
Appears in Collections:人獣共通感染症リサーチセンター (Research Center for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 木村 享史

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