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Flavivirus Encephalitis : Pathological Aspects of Mouse and Other Animal Models
| Title: | Flavivirus Encephalitis : Pathological Aspects of Mouse and Other Animal Models |
| Authors: | Kimura, T. Browse this author →KAKEN DB | | Sasaki, M. Browse this author | | Okumura, M. Browse this author | | Kim, E. Browse this author | | Sawa, H. Browse this author |
| Keywords: | experimental animal models | | Flavivirus | | histopathology | | Japanese encephalitis virus | | mice | | mosquito-borne encephalitis | | West Nile virus |
| Issue Date: | Sep-2010 |
| Publisher: | Sage Publications |
| Journal Title: | Veterinary Pathology |
| Volume: | 47 |
| Issue: | 5 |
| Start Page: | 806 |
| End Page: | 818 |
| Publisher DOI: | 10.1177/0300985810372507 |
| PMID: | 20551474 |
| Abstract: | Encephalitic flaviviruses are important arthropod-borne pathogens of humans and other animals. In particular, the recent emergence of the West Nile virus (WNV) and Japanese encephalitis virus (JEV) in new geographic areas has caused a considerable public health alert and international concern. Among the experimental in vivo models of WNV and JEV infection, mice and other laboratory rodents are the most thoroughly studied and well-characterized systems, having provided data that are important for understanding the infectious process in humans. Macaca monkeys have also been used as a model for WNV and JEV infection, mainly for the evaluation of vaccine efficacy, whereas a limited number of published studies address pathomorphology. These animal models develop encephalitis with many similarities to the human disease; however, the histological events that occur during infection, especially in peripheral tissues, have not been fully characterized. |
| Rights: | The final, definitive version of this article has been published in the Journal, Veterinary Pathology, 47/5, 2010 of publication, © American College of Veterinary Pathologists, 2010 by SAGE Publications Ltd at the Veterinary Pathology page: http://vet.sagepub.com/ on SAGE Journals Online: http://online.sagepub.com/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/47038 |
| Appears in Collections: | 人獣共通感染症国際共同研究所 (International Institute for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 木村 享史
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