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Comparison of airway remodelling assessed by computed tomography in asthma and COPD

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Title: Comparison of airway remodelling assessed by computed tomography in asthma and COPD
Authors: Shimizu, Kaoruko Browse this author
Hasegawa, Masaru Browse this author
Makita, Hironi Browse this author
Nasuhara, Yasuyuki Browse this author
Konno, Satoshi Browse this author
Nishimura, Masaharu Browse this author
Keywords: Airway remodelling
Asthma
COPD
Three-dimensional computed tomography
Issue Date: Sep-2011
Publisher: Elsevier
Journal Title: Respiratory Medicine
Volume: 105
Issue: 9
Start Page: 1275
End Page: 1283
Publisher DOI: 10.1016/j.rmed.2011.04.007
PMID: 21646007
Abstract: Background: Few studies have directly compared airway remodelling assessed by computed tomography (CT) between asthma and chronic obstructive pulmonary disease (COPD). The present study was conducted to determine whether there are any differences between the two diseases with similar levels of airflow limitation under clinically stable conditions. Methods: Subjects included older male asthmatic patients (n = 19) showing FEV1/FVC <70% with smoking history less than 5-pack/year. Age- and sex-matched COPD patients (n = 28) who demonstrated similar airflow limitation as asthmatic patients and age-matched healthy non-smokers (n = 13) were recruited. Using proprietary software, eight airways were selected in the right lung, and wall area percent (WA%) and airway luminal area (Ai) were measured at the mid-portion of the 3rd to 6th generation of each airway. For comparison, the average of eight measurements per generation was recorded. Results: FEV1% predicted and FEV1/FVC was similar between asthma and COPD (82.3 ± 3.3% vs. 77.6 ± 1.8% and 57.7 ± 1.6% vs. 57.9 ± 1.4%). At any generation, WA% was larger and Ai was smaller in asthma, both followed by COPD and then controls. Significant differences were observed between asthma and controls in WA% of the 3rd to 5th generation and Ai of any generation airway, while no differences were seen between COPD and controls. There were significant differences in Ai of any generation between asthma and COPD. Conclusions: Airway remodelling assessed by CT is more prominent in asthma compared with age- and sex-matched COPD subjects in the 3rd- to 6th-generation airways when airflow limitations were similar under stable clinical conditions.
Type: article (author version)
URI: http://hdl.handle.net/2115/47046
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 清水 薫子

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