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Identifying a new locus that regulates the development of rete ovarian cysts in MRL/MpJ mice

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Title: Identifying a new locus that regulates the development of rete ovarian cysts in MRL/MpJ mice
Authors: Lee, Shin-Hyo Browse this author
Ichii, Osamu Browse this author →KAKEN DB
Otsuka, Saori Browse this author →KAKEN DB
Hashimoto, Yoshiharu Browse this author →KAKEN DB
Namiki, Yuka Browse this author →KAKEN DB
Kon, Yasuhiro Browse this author →KAKEN DB
Keywords: cystic rete ovarii
MRL/MpJ mice
QTL analysis
rete ovarii
Issue Date: Aug-2011
Publisher: Graduate School of Veterinary Medicine, Hokkaido University
Journal Title: Japanese Journal of Veterinary Research
Volume: 59
Issue: 2&3
Start Page: 79
End Page: 88
Abstract: MRL/MpJ (MRL) is a mouse model for autoimmune disease and develops ovarian cysts with age. The ovarian cysts originate from the rete ovarii, which is considered to be the remnant of fetal mesonephric tubules. In a previous study, we analyzed the genetic background of ovarian cysts by using backcross progenies between MRL and C57BL/6N (B6) mice. By interval mapping, suggestive linkages were detected on several chromosomes (Chrs), and a significant linkage on Chr 14 was designated as MRL Rete Ovarian Cyst (mroc). In the present study, which evaluated 113 F2 intercross progenies, a significant linkage appeared on Chr 6 at the marker position D6Mit188 (likelihood ratio statistic = 18.5). In particular, the peak regions of Chrs 6 and 14, which contain major causative loci by backcross analysis, showed close reverse interaction. From these results, a locus on Chr 6 was identified as mroc2, the second major locus associated with ovarian cyst formation in MRL mice.
Type: bulletin (article)
Appears in Collections:Japanese Journal of Veterinary Research > Volume 59 Number 2&3

Submitter: 獣医学部図書室

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