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Primary acinar cell carcinoma of the ampulla of Vater.

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Title: Primary acinar cell carcinoma of the ampulla of Vater.
Authors: Kawakami, Hiroshi Browse this author
Kuwatani, Masaki Browse this author
Onodera, Manabu Browse this author
Hirano, Satoshi Browse this author
Kondo, Satoshi Browse this author
Nakanishi, Yoshitsugu Browse this author
Itoh, Tomoo Browse this author
Asaka, Masahiro Browse this author
Keywords: Ampullary neoplasms
Pancreatic neoplasms
Acinar cell carcinoma
Ampulla of Vater
Heterotopic pancreas
Issue Date: Aug-2007
Journal Title: Journal of gastroenterology
Volume: 42
Issue: 8
Start Page: 694
End Page: 697
Publisher DOI: 10.1007/s00535-007-2070-8
PMID: 17701134
Abstract: Acinar cell carcinoma of the pancreatobiliary system is a relatively rare malignant neoplasm arising usually in the pancreatic parenchyma. We experienced a 68-year-old woman who presented with obstructive jaundice due to an ampullary mass 1.0 cm in diameter, detected by abdominal computed tomography and endoscopic examination. The patient underwent a curative surgical operation, and histopathological examination revealed that the tumor was confined to the ampulla of Vater with no continuity to the pancreatic parenchyma. The tumor cells showed acinar or tubular arrangement with eosinophilic to basophilic granular cytoplasm, findings identical to those of acinar cell carcinoma of the pancreas. Immunohistochemically, the tumor cells were positive for lipase. From these findings, we concluded that the tumor was primary acinar cell carcinoma arising in the ampulla of Vater, probably originating from heterotopic pancreatic tissue. This is the first reported case of primary acinar cell carcinoma in the ampulla of Vater.
Rights: The original publication is available at
Type: article (author version)
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 河上 洋

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