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Dramatic changes of the gut flora immediately after severe and sudden insults.

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Title: Dramatic changes of the gut flora immediately after severe and sudden insults.
Authors: Hayakawa, Mineji Browse this author
Asahara, Takashi Browse this author
Henzan, Naomi Browse this author
Murakami, Hiromoto Browse this author
Yamamoto, Hiroshi Browse this author
Mukai, Nobutaka Browse this author
Minami, Yousuke Browse this author
Sugano, Masahiro Browse this author
Kubota, Nobuhiko Browse this author
Uegaki, Shinji Browse this author
Kamoshida, Hisako Browse this author
Sawamura, Atsushi Browse this author
Nomoto, Koji Browse this author
Gando, Satoshi Browse this author
Keywords: Critical illness
Bacterial translocation
Short-chain fatty acid
Issue Date: Aug-2011
Journal Title: Digestive diseases and sciences
Volume: 56
Issue: 8
Start Page: 2361
End Page: 2365
Publisher DOI: 10.1007/s10620-011-1649-3
PMID: 21384123
Abstract: Background The gut flora is crucially involved in host homeostasis. However, the changes in the gut flora during the early phase of a critical illness are unknown. Aims We investigated the changes in the gut flora at an early phase of severe insult in critically ill patients. Methods Fifteen patients who experienced a sudden and severe insult were studied, along with 12 healthy volunteers as the control group. Fecal samples were acquired from the subjects by swabs of the rectum within 6 h after admission to the emergency room (day 0). Samples were serially collected from patients until day 14. Samples were also collected from control subjects. Results On day 0, total bacterial counts were decreased to one-thousandth the number of the control subjects, in particular, obligate anaerobes and Lactobacillus were significantly decreased. In addition, on day 0, the major shortchain fatty acids of the patients were significantly lower than those of the control subjects. The gut flora and the concentrations of major short-chain fatty acids did not recover to normal levels. In contrast, Enterococcus and Pseudomonas increased during the study period
Rights: The original publication is available at
Type: article (author version)
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 早川 峰司

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