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Hokkaido University Collection of Scholarly and Academic Papers >
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Diazepam-Induced Increases of Synaptic Efficacy in the Hippocampal-Medial Prefrontal Cortex Pathway Are Associated With Its Anxiolytic-like Effect in Rats
| Title: | Diazepam-Induced Increases of Synaptic Efficacy in the Hippocampal-Medial Prefrontal Cortex Pathway Are Associated With Its Anxiolytic-like Effect in Rats |
| Authors: | Shikanai, Hiroki Browse this author | | Izumi, Takeshi Browse this author | | Matsumoto, Machiko Browse this author | | Togashi, Hiroko Browse this author | | Yamaguchi, Taku Browse this author | | Yoshida, Takayuki Browse this author | | Yoshioka, Mitsuhiro Browse this author →KAKEN DB |
| Keywords: | electrophysiology | | hippocampal-medial prefrontal cortex (mPFC) pathway | | behavior | | anxiety | | prefrontal cortex |
| Issue Date: | 2010 |
| Publisher: | Japanese Pharmacological Society |
| Journal Title: | Journal of Pharmacological Sciences |
| Volume: | 114 |
| Issue: | 3 |
| Start Page: | 341 |
| End Page: | 346 |
| Publisher DOI: | 10.1254/jphs.10182FP |
| Abstract: | The medial prefrontal cortex (mPFC) has recently been shown to be an important brain region for emotional function as well as cognitive ability. In previous experiments, we studied the population spike amplitude (PSA) in the mPFC induced by stimulation of the CA1/subicular region as an index of synaptic efficacy in the hippocampal-mPFC pathway. In the present study, we investigated the relationship between the anxiolytic effect of diazepam and the changes of synaptic efficacy in this pathway. In contextual fear conditioning tests, diazepam (0.1 mg/kg) was not effective for fear-related freezing behavior. At a dose of 0.5 mg/kg, diazepam decreased freezing behavior 20 min after administration, with no discernible effect 30 min after administration. In electrophysiological experiments, 0.1 mg/kg diazepam had no effect on the PSA in the mPFC. In contrast, 0.5 mg/kg diazepam increased the PSA in the mPFC within 30 min of administration; however, this PSA increase was attenuated over the 30-min period. Based on these results, we propose that the diazepam-induced PSA increase in the mPFC is associated with its anxiolytic-like effect. |
| Relation: | http://www.jstage.jst.go.jp/browse/jphs |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/47360 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 吉岡 充弘
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