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Diazepam-Induced Increases of Synaptic Efficacy in the Hippocampal-Medial Prefrontal Cortex Pathway Are Associated With Its Anxiolytic-like Effect in Rats

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Title: Diazepam-Induced Increases of Synaptic Efficacy in the Hippocampal-Medial Prefrontal Cortex Pathway Are Associated With Its Anxiolytic-like Effect in Rats
Authors: Shikanai, Hiroki Browse this author
Izumi, Takeshi Browse this author
Matsumoto, Machiko Browse this author
Togashi, Hiroko Browse this author
Yamaguchi, Taku Browse this author
Yoshida, Takayuki Browse this author
Yoshioka, Mitsuhiro Browse this author →KAKEN DB
Keywords: electrophysiology
hippocampal-medial prefrontal cortex (mPFC) pathway
behavior
anxiety
prefrontal cortex
Issue Date: 2010
Publisher: Japanese Pharmacological Society
Journal Title: Journal of Pharmacological Sciences
Volume: 114
Issue: 3
Start Page: 341
End Page: 346
Publisher DOI: 10.1254/jphs.10182FP
Abstract: The medial prefrontal cortex (mPFC) has recently been shown to be an important brain region for emotional function as well as cognitive ability. In previous experiments, we studied the population spike amplitude (PSA) in the mPFC induced by stimulation of the CA1/subicular region as an index of synaptic efficacy in the hippocampal-mPFC pathway. In the present study, we investigated the relationship between the anxiolytic effect of diazepam and the changes of synaptic efficacy in this pathway. In contextual fear conditioning tests, diazepam (0.1 mg/kg) was not effective for fear-related freezing behavior. At a dose of 0.5 mg/kg, diazepam decreased freezing behavior 20 min after administration, with no discernible effect 30 min after administration. In electrophysiological experiments, 0.1 mg/kg diazepam had no effect on the PSA in the mPFC. In contrast, 0.5 mg/kg diazepam increased the PSA in the mPFC within 30 min of administration; however, this PSA increase was attenuated over the 30-min period. Based on these results, we propose that the diazepam-induced PSA increase in the mPFC is associated with its anxiolytic-like effect.
Relation: http://www.jstage.jst.go.jp/browse/jphs
Type: article (author version)
URI: http://hdl.handle.net/2115/47360
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 吉岡 充弘

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