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Assessing the roles of presynaptic ryanodine receptors and adenosine receptors in caffeine-induced enhancement of hippocampal mossy fiber transmission
| Title: | Assessing the roles of presynaptic ryanodine receptors and adenosine receptors in caffeine-induced enhancement of hippocampal mossy fiber transmission |
| Authors: | Sato, Ikuma Browse this author | | Kamiya, Haruyuki Browse this author →KAKEN DB |
| Keywords: | Hippocampus | | Mossy fiber | | Caffeine | | Ryanodine receptor | | Presynapse | | Ca2+ store |
| Issue Date: | Oct-2011 |
| Publisher: | Elsevier Ireland |
| Journal Title: | Neuroscience Research |
| Volume: | 71 |
| Issue: | 2 |
| Start Page: | 183 |
| End Page: | 187 |
| Publisher DOI: | 10.1016/j.neures.2011.07.001 |
| PMID: | 21782858 |
| Abstract: | Caffeine robustly enhances transmitter release from the hippocampal mossy fiber terminals, although it remains uncertain whether calcium mobilization through presynaptic ryanodine receptors mediates this enhancement. In this study, we adopted a selective adenosine A1 blocker to assess relative contribution of A1 receptors and ryanodine receptors in caffeine-induced synaptic enhancement. Application of caffeine further enhanced transmission at the hippocampal mossy fiber synapse even after full blockade of adenosine A1 receptors. This result suggests that caffeine enhances mossy fiber synaptic transmission by two distinct presynaptic mechanisms, i.e., removal of A1 receptor-mediated tonic inhibition and ryanodine receptor-mediated calcium release from intracellular stores. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/47363 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 神谷 温之
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