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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine >
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Puumala virus infection in Syrian hamsters (Mesocricetus auratus) resembling hantavirus infection in natural rodent hosts
| Title: | Puumala virus infection in Syrian hamsters (Mesocricetus auratus) resembling hantavirus infection in natural rodent hosts |
| Authors: | Sanada, Takahiro Browse this author | | Kariwa, Hiroaki Browse this author →KAKEN DB | | Nagata, Noriyo Browse this author →KAKEN DB | | Tanikawa, Yoichi Browse this author | | Seto, Takahiro Browse this author | | Yoshimatsu, Kumiko Browse this author | | Arikawa, Jiro Browse this author →KAKEN DB | | Yoshii, Kentaro Browse this author →KAKEN DB | | Takashima, Ikuo Browse this author →KAKEN DB |
| Keywords: | Hantavirus | | Puumala virus | | Animal model | | Persistent infection | | Hamster |
| Issue Date: | Sep-2011 |
| Publisher: | Elsevier B.V. |
| Journal Title: | Virus Research |
| Volume: | 160 |
| Issue: | 1-2 |
| Start Page: | 108 |
| End Page: | 119 |
| Publisher DOI: | 10.1016/j.virusres.2011.05.021 |
| PMID: | 21672562 |
| Abstract: | The mechanism of hantavirus persistent infection in natural hosts is poorly understood due to a lack of laboratory animal models. Herein, we report that Syrian hamsters (Mesocricetus auratus) infected with Puumala virus (PUUV) at 4 weeks old show persistent infection without clinical symptoms for more than 2 months. IgG and IgM antibodies against the viral nucleocapsid protein and neutralizing antibody were first detectable at 14 days postinoculation (dpi) and maintained through 70 dpi. Viral RNA was first detected from 3 dpi in lungs and blood clots, and was detected in all tissues tested at 7 dpi. The viral RNA persisted for at least 70 days in the lungs, kidney, spleen, heart, and brain. The highest level of RNA copies was observed at 14 dpi in the lungs. Slight inflammatory reactions were observed in the lungs, adrenal glands, and brain. Immunohistochemical analysis revealed that PUUV antigen persisted until 56 dpi in the kidneys and adrenal glands. Infected hamsters showed no body weight loss or clinical signs. These results indicate that PUUV infection in hamsters is quite similar to the hantavirus infection of natural host rodents. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/47378 |
| Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 苅和 宏明
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