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Puumala virus infection in Syrian hamsters (Mesocricetus auratus) resembling hantavirus infection in natural rodent hosts

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Title: Puumala virus infection in Syrian hamsters (Mesocricetus auratus) resembling hantavirus infection in natural rodent hosts
Authors: Sanada, Takahiro Browse this author
Kariwa, Hiroaki Browse this author →KAKEN DB
Nagata, Noriyo Browse this author →KAKEN DB
Tanikawa, Yoichi Browse this author
Seto, Takahiro Browse this author
Yoshimatsu, Kumiko Browse this author
Arikawa, Jiro Browse this author →KAKEN DB
Yoshii, Kentaro Browse this author →KAKEN DB
Takashima, Ikuo Browse this author →KAKEN DB
Keywords: Hantavirus
Puumala virus
Animal model
Persistent infection
Issue Date: Sep-2011
Publisher: Elsevier B.V.
Journal Title: Virus Research
Volume: 160
Issue: 1-2
Start Page: 108
End Page: 119
Publisher DOI: 10.1016/j.virusres.2011.05.021
PMID: 21672562
Abstract: The mechanism of hantavirus persistent infection in natural hosts is poorly understood due to a lack of laboratory animal models. Herein, we report that Syrian hamsters (Mesocricetus auratus) infected with Puumala virus (PUUV) at 4 weeks old show persistent infection without clinical symptoms for more than 2 months. IgG and IgM antibodies against the viral nucleocapsid protein and neutralizing antibody were first detectable at 14 days postinoculation (dpi) and maintained through 70 dpi. Viral RNA was first detected from 3 dpi in lungs and blood clots, and was detected in all tissues tested at 7 dpi. The viral RNA persisted for at least 70 days in the lungs, kidney, spleen, heart, and brain. The highest level of RNA copies was observed at 14 dpi in the lungs. Slight inflammatory reactions were observed in the lungs, adrenal glands, and brain. Immunohistochemical analysis revealed that PUUV antigen persisted until 56 dpi in the kidneys and adrenal glands. Infected hamsters showed no body weight loss or clinical signs. These results indicate that PUUV infection in hamsters is quite similar to the hantavirus infection of natural host rodents.
Type: article (author version)
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 苅和 宏明

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