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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Environmental Science / Faculty of Environmental Earth Science >
Peer-reviewed Journal Articles, etc >
Bisphenol-A suppresses neurite extension due to inhibition of phosphorylation of mitogen-activated protein kinase in PC12 cells
| Title: | Bisphenol-A suppresses neurite extension due to inhibition of phosphorylation of mitogen-activated protein kinase in PC12 cells |
| Authors: | Seki, Sayaka Browse this author | | Aoki, Miho Browse this author | | Hosokawa, Toshiyuki Browse this author | | Saito, Takeshi Browse this author | | Masuma, Runa Browse this author | | Komori, Miyako Browse this author | | Kurasaki, Masaaki Browse this author |
| Keywords: | Bisphenol-A | | PC12 cell | | MAPK | | ERK | | Neurite | | Nerve growth factor |
| Issue Date: | 15-Oct-2011 |
| Publisher: | Elsevier Ireland |
| Journal Title: | Chemico-Biological Interactions |
| Volume: | 194 |
| Issue: | 1 |
| Start Page: | 23 |
| End Page: | 30 |
| Publisher DOI: | 10.1016/j.cbi.2011.08.001 |
| PMID: | 21871873 |
| Abstract: | An endocrine disrupter, bisphenol-A is widely used in the production of plastics and coatings. Recently, it was reported that bisphenol-A affected neurotransmitters in the mammalian brain. On the basis of these reports, it was considered that bisphenol-A affected neuronal differentiation. In this study, the morphological changes in nerve growth factor (NFG)-induced differentiation caused by bisphenol-A were confirmed using a PC12 cell system. When a low concentration of bisphenol-A was added to medium containing NGF, it inhibited neurite extension. In addition, to clarify whether bisphenol-A affects the early and late stages of the NGF-signaling pathway in cell differentiation, changes of phosphorylation of MAP kinases and cAMP-response element binding protein (CREB) in PC12 cells treated with and without BPA in medium containing NGF were investigated using western blot analysis. As results, bisphenol-A significantly inhibited phosphorylation of CREB and ERK1/2 MAPK. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/47398 |
| Appears in Collections: | 環境科学院・地球環境科学研究院 (Graduate School of Environmental Science / Faculty of Environmental Earth Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 藏崎 正明
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