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Bisphenol-A suppresses neurite extension due to inhibition of phosphorylation of mitogen-activated protein kinase in PC12 cells

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/47398

Title: Bisphenol-A suppresses neurite extension due to inhibition of phosphorylation of mitogen-activated protein kinase in PC12 cells
Authors: Seki, Sayaka Browse this author
Aoki, Miho Browse this author
Hosokawa, Toshiyuki Browse this author
Saito, Takeshi Browse this author
Masuma, Runa Browse this author
Komori, Miyako Browse this author
Kurasaki, Masaaki Browse this author
Keywords: Bisphenol-A
PC12 cell
MAPK
ERK
Neurite
Nerve growth factor
Issue Date: 15-Oct-2011
Publisher: Elsevier Ireland
Journal Title: Chemico-Biological Interactions
Volume: 194
Issue: 1
Start Page: 23
End Page: 30
Publisher DOI: 10.1016/j.cbi.2011.08.001
PMID: 21871873
Abstract: An endocrine disrupter, bisphenol-A is widely used in the production of plastics and coatings. Recently, it was reported that bisphenol-A affected neurotransmitters in the mammalian brain. On the basis of these reports, it was considered that bisphenol-A affected neuronal differentiation. In this study, the morphological changes in nerve growth factor (NFG)-induced differentiation caused by bisphenol-A were confirmed using a PC12 cell system. When a low concentration of bisphenol-A was added to medium containing NGF, it inhibited neurite extension. In addition, to clarify whether bisphenol-A affects the early and late stages of the NGF-signaling pathway in cell differentiation, changes of phosphorylation of MAP kinases and cAMP-response element binding protein (CREB) in PC12 cells treated with and without BPA in medium containing NGF were investigated using western blot analysis. As results, bisphenol-A significantly inhibited phosphorylation of CREB and ERK1/2 MAPK.
Type: article (author version)
URI: http://hdl.handle.net/2115/47398
Appears in Collections:環境科学院・地球環境科学研究院 (Graduate School of Environmental Science / Faculty of Environmental Earth Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 藏崎 正明

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