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Hokkaido University Collection of Scholarly and Academic Papers >
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Mitochondrial genome deletions and minicircles are common in lice (Insecta: Phthiraptera)
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| Title: | Mitochondrial genome deletions and minicircles are common in lice (Insecta: Phthiraptera) |
| Authors: | Cameron, Stephen L Browse this author | | Yoshizawa, Kazunori Browse this author →KAKEN DB | | Mizukoshi, Atsushi Browse this author | | Whiting, Michael F Browse this author | | Johnson, Kevin P Browse this author |
| Issue Date: | 2011 |
| Publisher: | BioMed Central |
| Journal Title: | BMC Genomics |
| Volume: | 12 |
| Issue: | 1 |
| Start Page: | 394 |
| Publisher DOI: | 10.1186/1471-2164-12-394 |
| Abstract: | Background: The gene composition, gene order and structure of the mitochondrial genome are remarkably stable across bilaterian animals. Lice (Insecta: Phthiraptera) are a major exception to this genomic stability in that the canonical single chromosome with 37 genes found in almost all other bilaterians has been lost in multiple lineages in favour of multiple, minicircular chromosomes with less than 37 genes on each chromosome. Results: Minicircular mt genomes are found in six of the ten louse species examined to date and three types of minicircles were identified: heteroplasmic minicircles which coexist with full sized mt genomes (type 1); multigene chromosomes with short, simple control regions, we infer that the genome consists of several such chromosomes (type 2); and multiple, single to three gene chromosomes with large, complex control regions (type 3). Mapping minicircle types onto a phylogenetic tree of lice fails to show a pattern of their occurrence consistent with an evolutionary series of minicircle types. Analysis of the nuclear-encoded, mitochondrially-targetted genes inferred from the body louse, Pediculus, suggests that the loss of mitochondrial single-stranded binding protein (mtSSB) may be responsible for the presence of minicircles in at least species with the most derived type 3 minicircles (Pediculus, Damalinia). Conclusions: Minicircular mt genomes are common in lice and appear to have arisen multiple times within the group. Life history adaptive explanations which attribute minicircular mt genomes in lice to the adoption of bloodfeeding in the Anoplura are not supported by this expanded data set as minicircles are found in multiple nonblood feeding louse groups but are not found in the blood-feeding genus Heterodoxus. In contrast, a mechanist explanation based on the loss of mtSSB suggests that minicircles may be selectively favoured due to the incapacity of the mt replisome to synthesize long replicative products without mtSSB and thus the loss of this gene lead to the formation of minicircles in lice. |
| Rights: | The electronic version of this article is the complete one and can be found online at: http://www.biomedcentral.com/1471-2164/12/394 | | http://creativecommons.org/licenses/by-nc-sa/2.1/jp/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/47517 |
| Appears in Collections: | 農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 吉澤 和徳
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