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Quantitative analysis of coronary endothelial function with generator-produced 82Rb PET : comparison with 15O-labelled water PET

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Title: Quantitative analysis of coronary endothelial function with generator-produced 82Rb PET : comparison with 15O-labelled water PET
Authors: Yoshinaga, Keiichiro Browse this author →KAKEN DB
Manabe, Osamu Browse this author
Katoh, Chietsugu Browse this author
Chen, Li Browse this author
Klein, Ran Browse this author
Naya, Masanao Browse this author
deKemp, Robert A. Browse this author
Williams, Kathryn Browse this author
Beanlands, Rob S. B. Browse this author
Tamaki, Nagara Browse this author
Keywords: Blood flow
Positron emission tomography
Issue Date: Dec-2010
Publisher: Springer Berlin / Heidelberg
Journal Title: European Journal of Nuclear Medicine and Molecular Imaging
Volume: 37
Issue: 12
Start Page: 2233
End Page: 2241
Publisher DOI: 10.1007/s00259-010-1541-y
PMID: 20625721
Abstract: Purpose: Endothelial dysfunction is the earliest abnormality in the development of coronary atherosclerosis. Rubidium-82 (82Rb) is a generator-produced positron emission tomography (PET) myocardial perfusion tracer that is becoming more widely used. We aimed to develop a method for quantitative assessment of coronary endothelial function using the myocardial blood flow (MBF) response during a cold pressor test (CPT) in smokers, measured using 82Rb PET and ii) compare the results with those measured using 15O-water PET. Methods: MBF was assessed at rest and during CPT with 82Rb and 15O-water in 9 controls and 10 smokers. A one-compartment model with tracer extraction correction was used to estimate MBF with both tracers. CPT response was calculated as the ratio of MBF during CPT to MBF at rest. Results: At rest, measurements of MBF for smokers vs. controls were not different using 15O-water (0.86 ± 0.18 vs. 0.70 ± 0.13, p = 0.426) than they were using 82Rb (0.83 ± 0.23 vs. 0.62 ± 0.20, p = 0.051). Both methods showed a reduced CPT response in smokers vs. controls (15O-water, 1.03 ± 0.21 vs. 1.42 ± 0.29, p = 0.006; 82Rb, 1.02 ± 0.28 vs. 1.70 ± 0.52, p < 0.001). There was high reliability [intra-class correlation coefficients: 0.48 (0.07, 0.75)] of MBF measurement between 82Rb and 15O-water during CPT. Conclusions: Using CPT, 82Rb MBF measurements detected coronary endothelial dysfunctions in smokers. 82Rb MBF measurements were comparable to those made using the 15O-water approach. Thus, 82Rb PET may be applicable for risk assessments or evaluation of risk factor modification in subjects with coronary risk factors.
Rights: The original publication is available at
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 吉永 恵一郎

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