| Title: | Quantitative analysis of coronary endothelial function with generator-produced 82Rb PET : comparison with 15O-labelled water PET |
| Authors: | Yoshinaga, Keiichiro Browse this author →KAKEN DB |
| Manabe, Osamu Browse this author |
| Katoh, Chietsugu Browse this author |
| Chen, Li Browse this author |
| Klein, Ran Browse this author |
| Naya, Masanao Browse this author |
| deKemp, Robert A. Browse this author |
| Williams, Kathryn Browse this author |
| Beanlands, Rob S. B. Browse this author |
| Tamaki, Nagara Browse this author |
| Keywords: | Blood flow |
| Endothelium |
| Positron emission tomography |
| Smoking |
| Issue Date: | Dec-2010 |
| Publisher: | Springer Berlin / Heidelberg |
| Journal Title: | European Journal of Nuclear Medicine and Molecular Imaging |
| Volume: | 37 |
| Issue: | 12 |
| Start Page: | 2233 |
| End Page: | 2241 |
| Publisher DOI: | 10.1007/s00259-010-1541-y |
| PMID: | 20625721 |
| Abstract: | Purpose: Endothelial dysfunction is the earliest abnormality in the development of coronary atherosclerosis. Rubidium-82 (82Rb) is a generator-produced positron emission tomography (PET) myocardial perfusion tracer that is becoming more widely used. We aimed to develop a method for quantitative assessment of coronary endothelial function using the myocardial blood flow (MBF) response during a cold pressor test (CPT) in smokers, measured using 82Rb PET and ii) compare the results with those measured using 15O-water PET. Methods: MBF was assessed at rest and during CPT with 82Rb and 15O-water in 9 controls and 10 smokers. A one-compartment model with tracer extraction correction was used to estimate MBF with both tracers. CPT response was calculated as the ratio of MBF during CPT to MBF at rest. Results: At rest, measurements of MBF for smokers vs. controls were not different using 15O-water (0.86 ± 0.18 vs. 0.70 ± 0.13, p = 0.426) than they were using 82Rb (0.83 ± 0.23 vs. 0.62 ± 0.20, p = 0.051). Both methods showed a reduced CPT response in smokers vs. controls (15O-water, 1.03 ± 0.21 vs. 1.42 ± 0.29, p = 0.006; 82Rb, 1.02 ± 0.28 vs. 1.70 ± 0.52, p < 0.001). There was high reliability [intra-class correlation coefficients: 0.48 (0.07, 0.75)] of MBF measurement between 82Rb and 15O-water during CPT. Conclusions: Using CPT, 82Rb MBF measurements detected coronary endothelial dysfunctions in smokers. 82Rb MBF measurements were comparable to those made using the 15O-water approach. Thus, 82Rb PET may be applicable for risk assessments or evaluation of risk factor modification in subjects with coronary risk factors. |
| Rights: | The original publication is available at www.springerlink.com |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/47526 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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