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A Case of Follicular Bronchiolitis Associated with Asthma, Eosinophilia, and Increased Immunoglobulin E

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Title: A Case of Follicular Bronchiolitis Associated with Asthma, Eosinophilia, and Increased Immunoglobulin E
Authors: Shimizu, Kaoruko Browse this author →KAKEN DB
Konno, Satoshi Browse this author →KAKEN DB
Nasuhara, Yasuyuki Browse this author →KAKEN DB
Tanino, Mishie Browse this author →KAKEN DB
Matsuno, Yoshihiro Browse this author →KAKEN DB
Nishimura, Masaharu Browse this author →KAKEN DB
Keywords: asthma
follicular bronchiolitis
MALT lymphoma
Issue Date: Dec-2010
Publisher: Informa Healthcare
Journal Title: Journal of Asthma
Volume: 47
Issue: 10
Start Page: 1161
End Page: 1164
Publisher DOI: 10.3109/02770903.2010.515326
PMID: 21039211
Abstract: A 49-year-old woman, who had been diagnosed with asthma, showed a bilateral diffuse pattern of small centrilobular nodules on CT. Laboratory data revealed peripheral eosinophilia and a marked increase in total serum IgE levels. The nodules detected on CT were initially considered to be associated with bronchiolar infiltration of eosinophils. Pathological findings from thoracoscopy revealed infiltration of eosinophils into the airway lumen and walls, goblet cell hyperplasia, and thickening of the basement membrane in large bronchi, consistent with asthma. However, hyperplastic lymphoid follicles with reactive germinal centers were observed along the bronchioles. The follicles had no evidence of monoclonality suggested by immunohistological analysis, and no remarkable infiltrates of eosinophils, suggesting follicular bronchiolitis. After treatment with prednisolone, the small diffuse nodules improved markedly, and peripheral eosinophilia and total serum IgE levels also decreased. To the best of our knowledge, this is the first documented case report of follicular bronchiolitis associated with asthma, eosinophilia, and elevated IgE with a definite pathophysiological diagnosis.
Rights: Copyright © 2010 Informa Plc.
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 清水 薫子

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