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Endothelin Type B Receptor–Induced Sustained Ca2+ Influx Involves Gq/11/Phospholipase C–Independent, p38 Mitogen-Activated Protein Kinase–Dependent Activation of Na+/H+ Exchanger

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Title: Endothelin Type B Receptor–Induced Sustained Ca2+ Influx Involves Gq/11/Phospholipase C–Independent, p38 Mitogen-Activated Protein Kinase–Dependent Activation of Na+/H+ Exchanger
Authors: Higa, Tsunaki Browse this author
Horinouchi, Takahiro Browse this author →KAKEN DB
Aoyagi, Hiroyuki Browse this author
Asano, Hiroshi Browse this author
Nishiya, Tadashi Browse this author
Nishimoto, Arata Browse this author
Muramatsu, Ikunobu Browse this author
Miwa, Soichi Browse this author
Keywords: endothelin type B receptor
Na+/H+ exchanger
p38 mitogen-activated protein kinase
Issue Date: Jul-2010
Publisher: Japanese Pharmacological Society
Journal Title: Journal of Pharmacological Sciences
Volume: 113
Issue: 3
Start Page: 276
End Page: 280
Publisher DOI: 10.1254/jphs.10102SC
Abstract: The mechanism for sustained Ca2+ influx activated by G protein-coupled receptors was examined. In Chinese hamster ovary cells expressing recombinant human endothelin type B receptor (ETBR) and endogenous P2Y receptor (P2Y-R), endothelin-1 elicited a sustained Ca2+ influx depending on Gq/11 protein, phospholipase C (PLC), Na+/H+ exchanger (NHE) and p38 mitogen-activated protein kinase (p38MAPK), whereas P2Y-R-induced sustained Ca2+ influx was negligible. Functional study showed that NHE activation by ETBR was mediated via p38MAPK but not Gq/11/PLC, while that by P2Y-R involves only Gq/11/PLC/p38MAPK. These results suggest that Gq/11/PLC-independent NHE activation via p38MAPK plays an important role in ETBR-mediated sustained Ca2+ influx.
Relation: http://www.jstage.jst.go.jp/browse/jphs
Type: article (author version)
URI: http://hdl.handle.net/2115/47620
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 堀之内 孝広

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