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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >
Endothelin Type B Receptor–Induced Sustained Ca2+ Influx Involves Gq/11/Phospholipase C–Independent, p38 Mitogen-Activated Protein Kinase–Dependent Activation of Na+/H+ Exchanger
| Title: | Endothelin Type B Receptor–Induced Sustained Ca2+ Influx Involves Gq/11/Phospholipase C–Independent, p38 Mitogen-Activated Protein Kinase–Dependent Activation of Na+/H+ Exchanger |
| Authors: | Higa, Tsunaki Browse this author | | Horinouchi, Takahiro Browse this author →KAKEN DB | | Aoyagi, Hiroyuki Browse this author | | Asano, Hiroshi Browse this author | | Nishiya, Tadashi Browse this author | | Nishimoto, Arata Browse this author | | Muramatsu, Ikunobu Browse this author | | Miwa, Soichi Browse this author |
| Keywords: | endothelin type B receptor | | Na+/H+ exchanger | | p38 mitogen-activated protein kinase |
| Issue Date: | Jul-2010 |
| Publisher: | Japanese Pharmacological Society |
| Journal Title: | Journal of Pharmacological Sciences |
| Volume: | 113 |
| Issue: | 3 |
| Start Page: | 276 |
| End Page: | 280 |
| Publisher DOI: | 10.1254/jphs.10102SC |
| Abstract: | The mechanism for sustained Ca2+ influx activated by G protein-coupled receptors was examined. In Chinese hamster ovary cells expressing recombinant human endothelin type B receptor (ETBR) and endogenous P2Y receptor (P2Y-R), endothelin-1 elicited a sustained Ca2+ influx depending on Gq/11 protein, phospholipase C (PLC), Na+/H+ exchanger (NHE) and p38 mitogen-activated protein kinase (p38MAPK), whereas P2Y-R-induced sustained Ca2+ influx was negligible. Functional study showed that NHE activation by ETBR was mediated via p38MAPK but not Gq/11/PLC, while that by P2Y-R involves only Gq/11/PLC/p38MAPK. These results suggest that Gq/11/PLC-independent NHE activation via p38MAPK plays an important role in ETBR-mediated sustained Ca2+ influx. |
| Relation: | http://www.jstage.jst.go.jp/browse/jphs |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/47620 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 堀之内 孝広
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